Research progress of ghrelin in maintaining metabolism and energy homeostasis

doi:10.11852/zgetbjzz2022-0327

Abstract

Abstract: Ghrelin is a 28-amino acid polypeptide discovered in 1999. It is secreted by X/ A-like cells in the stomach and promotes the release of growth hormone. It is also an appetite stimulating peptide. Ghrelin acts on the Ghrelin-GHS-R axis to maintain metabolism and energy homeostasis. In this review, a series of studies and advances related to ghrelin physiology, pathophysiology, animal experiments and clinical practice are combed. The role of ghrelin in maintaining metabolism and energy homeostasis in the body is introduced, and the possible reasons for the controversial results are analyzed. The importance of detecting method in determining the level and ratio of acyl ghrelin anddes-acylated ghrelin in circulation is emphasized, suggesting that ghrelin has a positive effect on the prevention and treatment of various diseases.

Key words: acyl ghrelin, des-acylated ghrelin, energy homeostasis

摘要： 胃饥饿素是1999年被发现的具有28个氨基酸的多肽,由胃X/A样细胞分泌,促进生长激素的释放,同时也是一种促食欲肽。胃饥饿素通过Ghrelin-GHS-R轴发挥作用,维持机体代谢及能量稳态。本篇综述回顾了有关胃饥饿素生理、病理生理、动物实验及临床相关的系列研究及进展,介绍了胃饥饿素在维持机体代谢及能量稳态方面的作用,分析了导致具有争议的研究结果的可能原因,强调了检测方法在测定循环中酰基胃饥饿素和去酰基胃饥饿素水平和比例的重要性,提示胃饥饿素对多种疾病的预防及治疗具有积极作用。

关键词: 酰基胃饥饿素, 去酰基胃饥饿素, 能量稳态

CLC Number:

R333.2

ZHANG Li, LI Dong. Research progress of ghrelin in maintaining metabolism and energy homeostasis[J]. Chinese Journal of Child Health Care, 2022, 30(9): 994-999.

张莉, 李冬. 胃饥饿素维持代谢及能量稳态作用的研究进展[J]. 中国儿童保健杂志, 2022, 30(9): 994-999.

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