Advances and reflections on nutrient signalling pathways as biomarkers of autism spectrum disorders

doi:10.11852/zgetbjzz2022-0335

Abstract

Abstract: Autism spectrum disorder (ASD) is a common and complex neurodevelopmental disorder. Nutrition plays an important role in the growth and development of children, and there is a certain relationship with the occurrence, development and prognosis of ASD subtypes. With the deepening of research, correlating ASD symptoms with serum nutrient levels has been extremely challenging. This manuscript takes folic acid and vitamin A (VA) as examples to review the new ideas of using nutrient signaling pathway as a potential biomarker of ASD, hoping to provide reference for further exploring the occurrence, diagnosis and treatment of ASD.

Key words: autism spectrum disorder, nutrients, child nutrition, genetic background, signalling pathways

摘要： 孤独症谱系障碍(ASD)是常见的复杂神经发育障碍,营养是儿童生长发育的重要因素,其与ASD亚型的发生、发展及预后存在一定关联,随着研究的深入,发现单用血清营养素水平关联ASD的症状受到极大挑战。本文以叶酸、维生素A(VA)为例综述了将营养素信号通路作为ASD潜在生物标志物的新思路,望对进一步探寻ASD的发生、诊治起到抛砖引玉作用。

关键词: 孤独症谱系障碍, 营养素, 儿童营养, 遗传背景, 信号通路

CLC Number:

R749.94

LI Ting-yu. Advances and reflections on nutrient signalling pathways as biomarkers of autism spectrum disorders[J]. Chinese Journal of Child Health Care, 2022, 30(4): 349-351.

李廷玉. 营养素信号通路作为孤独症谱系障碍生物标志的进展和思考[J]. 中国儿童保健杂志, 2022, 30(4): 349-351.

References

[1] Maenner MJ, Shaw KA, Baio J, et al. Prevalence of autism spectrum disorder among children aged 8 years-autism and developmental disabilities monitoring network, 11 Sites, United States, 2016[J]. MMWR Surveill Summ, 2020, 69(4): 1-12.
[2] Maenner MJ, Shaw KA, Bakian AV, et al. Prevalence and characteristics of autism spectrum disorder among children aged 8 years-autism and developmental disabilities monitoring network, 11 sites, United States, 2018[J]. MMWR Surveill Summ, 2021, 70(11):1-16.
[3] Zhou H, Xu X, Yan WL, et al. Prevalence of autism spectrum disorder in china: a nationwide multi-center population-based study among children aged 6 to 12 years[J]. Neurosci Bull,2020, 36(9):961-971.
[4] Li MY, Francis E, Hinkle SN, et al. Preconception and prenatal nutrition and neurodevelopmental disorders: A systematic review and meta-analysis[J]. Nutrients, 2019,11(7):1628.
[5] Raghavan R, Riley AW, Volk H, et al. Maternal multivitamin intake, plasma folate and vitamin B(12) levels and autism spectrum disorder risk in offspring[J].2018, 32(1):100-111.
[6] Sun CH, Zou MY, Zhao D, et al. Efficacy of folic acid supplementation in autistic children participating in structured teaching: An open-label trial[J]. Nutrients, 2016, 8(6): 337.
[7] Li Q, Yang T, Chen L, et al. Serum folate status is primarily associated with neurodevelopment in children with autism spectrum disorders aged three and under——A multi-center study in China[J]. Front Nutr,2021,8:661223.
[8] 张霆,吴建新,李廷玉.儿童营养表观遗传学[M]. 北京:科学出版社, 2019.
[9] Zieger E, Schubert M. New insights into the roles of retinoic acid signaling in nervous system development and the establishment of neurotransmitter systems[J]. Int Rev Cell Mol Biol, 2017, 330: 1-84.
[10] Maden M. Retinoic acid in the development, regeneration and maintenance of the nervous system[J]. Nat Rev Neurosci,2007,8(10): 755-756.
[11] Shibata M, Pattabiraman K, Lorente-galdos B, et al. Regulation of prefrontal patterning and connectivity by retinoic acid[J]. Nature, 2021, 598(7881):483-488.
[12] Shibata M, Pattabiraman K, Muchnik S, et al. Hominini-specific regulation of CBLN2 increases prefrontal spinogenesis[J].Nature, 598(7881): 489-494.
[13] Liu ZH, Wang JY, Xu Q, et al.Research progress in vitamin A and autism spectrum disorder[J].Behav Neurol,2021:5417497.
[14] Lai X, Wu XF, Hou NL, et al. Vitamin A deficiency induces autistic-like behaviors in rats by regulating the RARβ-CD38-oxytocin axis in the hypothalamus[J]. Mol Nutr Food Res, 2018, 62(5). doi: 10.1002/mnfr.201700754.
[15] Liu H, Tan M, Cheng BL, et al. Valproic acid induces autism-like synaptic and behavioral deficits by disrupting histone acetylation of prefrontal cortex ALDH1A1 in rats[J].Front Neurosci, 2021, 15: 641284.
[16] Hao ZJ, Wu QH, Li ZW, et al. Maternal exposure to triclosan constitutes a yet unrecognized risk factor for autism spectrum disorders[J]. Cell Res, 2019, 29(10):866-869.