Abstract: Objective To investigate the effect of comprehensive intervention on nervous development and timeliness of intervention for high risk infant with brain damage. Methods High risk infant with brain damage were divided into intervention and non-intervention groups according to compliance principle.The intervention groups were divided into intervention group of neonatal period(group A),intervention group of infancy period(group B) and intervention group of early childhood(group C) according to the different intervention time,while normal infants born in the same period selected as the control group(group E).The differences of movement,intelligence and neurodevelopment outcomes were analyzed. Results Except the NBNA score of group A was less than that of group E in the first week,there were similar with the levels of movement,intelligence and neurodevelopment outcomes between group A and group E.Evaluations of motor development,ratios of low intelligence and cerebral palsy were indicated that the effect of intervention group was better than non-intervention group(group D),the results of group A and group B were also better than those in group C(P<0.05). Conclusion Brain damage can lead to damage of movement,intelligent and neurodevelopment of infant to a certain extent.Comprehensive intervention have the improving results and the earlier is better.

Key words: brain damage, comprehensive intervention, nervous development, cerebral palsy

摘要： 目的 探讨综合干预对脑损伤高危儿神经系统发育的影响和干预时效性。方法 选择脑损伤高危儿,按照干预依从性原则,分为非干预组和干预组。干预组又根据干预时间窗分为新生儿期干预组(A组)、婴儿期干预组(B组)和幼儿期干预组(C组),同时选择同期出生的正常婴幼儿为对照组(E组)。分析不同组别婴幼儿运动、智能和神经发育结局。结果 新生儿期干预组除生后1周NBNA评分低于正常对照组外,各运动发育的建立时间、智能和神经发育水平均接近正常对照组。而各运动发育的建立时间评价发现,干预组优于非干预组,且新生儿期和婴儿期干预效果优于幼儿期干预组;智能低下和脑瘫的发生率比较发现,干预组优于非干预组(D组),且新生儿期和婴幼儿干预效果优于幼儿期干预组,差异均有统计学意义(P<0.05)。结论 脑损伤一定程度上导致婴幼儿运动、智能和神经发育损伤,而综合干预有明显改善效果,干预时间越早效果越好。

关键词: 脑损伤, 综合干预, 神经发育, 脑瘫