journal1 ›› 2021, Vol. 29 ›› Issue (3): 281-284.DOI: 10.11852/zgetbjzz2020-0115

• Review • Previous Articles     Next Articles

Research progress on intestinal barrier dysfunction in necrotizing enterocolitis

YANG Meng-yang, JIANG Min   

  1. Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
  • Received:2020-01-28 Revised:2020-02-22 Online:2021-03-10 Published:2021-03-10
  • Contact: JIANG Min,


杨梦阳, 姜敏   

  1. 首都医科大学附属北京儿童医院新生儿中心,北京 100045
  • 通讯作者: 姜敏,
  • 作者简介:杨梦阳(1996-),女,安徽人,在读硕士研究生,主要研究方向为新生儿疾病。

Abstract: Necrotizing enterocolitis (NEC) is a common and serious disease of digestive system during neonatal period, which is one of the main cause of premature death. Intestinal barrier function is underdeveloped in preterm infants, and many pathogenic factors may induce intestinal barrier dysfunction, causing the intestinal mechanical barrier damage, the delay of microbial barrier establishment, the immature of immune barriers, thereby inducing inflammatory cascade reaction and the occurrence of NEC. Early diagnosis of NEC is extremely important for its treatment and prognosis, and the researches on intestinal barrier dysfunction markers are expected to improve the specificity and sensitivity of early diagnosis of NEC. This paper reviews the research progress on intestinal barrier dysfunction in NEC, in order to deepen the understanding of the role of intestinal barrier in the pathogenesis of NEC, and to provide more ideas for the prevention and treatment of NEC.

Key words: necrotizing enterocolitis, intestinal barrier dysfunction, biomarkers, neonates

摘要: 坏死性小肠结肠炎(NEC)是一种常见的严重危及新生儿,尤其是早产儿生命的消化系统疾病。早产儿肠道屏障功能不成熟,很多致病因素可诱发肠屏障功能障碍,造成肠机械屏障损害,微生物屏障建立延迟,免疫屏障发育不成熟,从而引发炎症级联反应导致NEC 的发生。早期诊断NEC对于其治疗和预后极其重要,肠道屏障功能损伤标志物的研究有望提高NEC早期诊断的特异性和敏感性。本文通过综述NEC肠道屏障功能障碍的研究进展,以加深认识肠屏障在NEC 发病过程中的作用,为NEC的防治提供更多思路。

关键词: 坏死性小肠结肠炎, 肠屏障功能, 生物标志物, 新生儿

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