Abstract: The prevalence of autism spectrum disorder(ASD) is rising, which has become one of the main challenges of modern medicine. In addition to the core symptoms such as continuous damage to social interaction and limited and repeated interests, activities or behavior patterns, it will also be accompanied by gastrointestinal symptoms, irritability and aggressive behavior, emotional problems, hyperactivity symptoms, sleep problems, etc., which will bring heavy mental and economic burden to caregivers. At present, the etiology of ASD is not clear.The main treatment of ASD is behavioral therapy, and there is no effective drug to treat its core symptoms. In recent years, more and more attention has been paid to the potential mediating role of gut microbiom as risk factors in patients with ASD. Several clinical studies have shown that changes of gut microbiom can not only improve the gastrointestinal symptoms of ASD, but also improve its maladaptive behavior. Further studies are warranted to explore the effect of gut microbiom on ASD symptoms so as to provide more powerful evidence for clinical practice.

Key words: autism, gut microbiom, probiotics, probiotics, fecal microbiota transplant

摘要： 孤独症谱系障碍(ASD)患病率不断攀升,已成为现代医学面临的主要挑战之一。除了社交互动的持续损害和局限的、重复的兴趣、活动或行为模式这些核心症状之外,还会伴随如胃肠道症状、易怒和攻击行为、情绪问题、多动症状、睡眠问题等,给照料者带来沉重精神和经济负担。目前ASD病因尚不明确,治疗主要以行为改善为主,尚无有效药物可以治疗其核心症状。近年来,肠道微生物作为ASD患者危险因素的潜在中介作用受到越来越多的关注。临床研究表明:改变肠道微生物生态环境失调不仅可改善ASD的胃肠症状,还可改善其适应不良行为。未来需要更多的研究探索肠道微生物对ASD症状的影响,以期为临床提供更多有力的证据。

关键词: 孤独症谱系障碍, 肠道微生物, 益生菌, 益生元, 粪菌移植