Abstract: Objective To explore the cognitive function and behavioral problems in school-age children with ventricular septal defect (VSD) after transcatheter intervention.Methods Patients who underwent trans-catheter closure of ventricular septal defect at Provincial Hospital Affiliated to Shandong University between January 2010 and December 2012,were recruited and received a day-long series of assessments,including ERP and CBCL (parents report).Results Compared with healthy controls,the mean P300 latencies in Fz and Cz leads were longer,and the P300 amplitude in Fz and Cz leads were lower in VSD patients.The subscale scores of depression,somatic problems and internalizing were higher in the VSD boys.The subscale scores of depression,compulsory,social withdrawal and rule-broking behavior were higher in the VSD girls.For VSD boys with depression,the mean P300 latencies was longer and the P300 amplitude was lower in Cz leads.For VSD boys with somatic problems,the mean P300 latencies was longer in Fz leads.For VSD girls with depression,the mean P300 latencies was longer and the P300 amplitude was lower in Cz leads.For VSD girls with compulsory,the P300 amplitude was lower in Fz leads.For VSD girls with social withdrawal,the mean P300 latencies was longer in Fz leads.For VSD girls with rule-broking behavior,the P300 amplitude was lower in Cz leads.Conclusion School-aged children who underwent transcatheter occlusion of ventricular septal defect exhibit some behavioral problems which were related with abnormal event related potentials.

Key words: ventricular septal defect, school-aged children, event related potentials, behavioral problem

摘要： 目的 研究介入治疗后的室间隔缺损(VSD)患儿的认知能力及行为问题,分析两者之间的关联性。方法 选择自2010年1月-2012年12月在山东省立医院进行经导管介入封堵治疗的VSD 64例患儿。采用P300事件相关电位来评估VSD患儿的认知能力,另外采用儿童行为问题问卷来评估患儿的情绪和行为问题,分析这两者之间的关联性,并以56位正常对照儿童参与了本研究。结果 1)与对照组相比,VSD患儿在额叶和顶叶部位具有长的潜伏期,额叶和顶叶部位的波幅明显低于对照组;2)VSD的男童存在抑郁、体诉等行为问题,女童存在抑郁、强迫、社会退缩、违纪等行为问题;3)存在抑郁、体诉问题的VSD男童事件相关电位的异常分别表现为顶叶潜伏期延长、波幅降低及额叶潜伏期延长;4)存在抑郁、强迫、社会退缩、违纪问题的VSD女童事件相关电位的异常分别表现为顶叶潜伏期延长和波幅降低、额叶波幅降低、额叶潜伏期延长、顶叶波幅降低。结论 与正常儿童相比,介入治疗后的VSD患儿,学龄期的认知能力存在轻度的损害,且有一定程度的情绪和行为问题,VSD患儿的行为问题与异常的事件相关电位有一定的相关性。

关键词: 室间隔缺损, 学龄期儿童, 事件相关电位, 行为问题