journal1 ›› 2017, Vol. 25 ›› Issue (2): 164-166.DOI: 10.11852/zgetbjzz2017-25-02-16

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Diagnostic value of NBNA score combined head MRI in the neonates with severe hyperbilirubinemia for brain injury

ZHANG Hai-yan,QIAO Lin-xia,ZHU Wen-ying,WANG hua   

  1. Neonate Department,The First People's Hospital of Kunshan Affiliated to Jiangsu University,Kunshan,Jiangsu 215300,China
  • Received:2016-09-05 Online:2017-02-10 Published:2017-02-10
  • Contact: WANG Hua,



  1. 江苏大学附属昆山市第一人民医院新生儿科,江苏 昆山 215300
  • 通讯作者: 王华,
  • 作者简介:张海燕(1982-),女,江苏人,主治医师,硕士学位,主要研究方向为新生儿疾病。

Abstract: Objectives To investigate the diagnostic value of neonatal behavioral neurological assessment (NBNA) and magnetic resonance image (MRI) in the newborns' brain injury with severe hyperbilirubinemia. Methods 20 cases of newborns with severe hyperbilirubinemia brain injury were admitted between Sep.2013 and Sep.2015 as the research objects.MRI result was further analysised after using NBNA score and MRI.The control group (n=20) who were normal newborns accepted the examination of NBNA.Subsequently,the NBNA scores of the two groups was analysised.The infants with MRI signal abnormality were rechecked at the age of 6 months. Results The NBNA scores of research objects were significantly lower than that of control group.In the 20 cases,9 cases with MRI signal abnormality and 11 cases without any pallidum signal changing.The NBNA scores of the abnormal MRI group were lower than that of the normal group.And there were no abnormal signals when recheck in their 6 month. Conclusions MRI scans is particularly important during the diagnosis of the newborns' brain injury.The NBNA score and head MRI can be used as the index of early diagnosis for brain injury in newborns.

Key words: neonatal behavioral neurological assessment score, magnetic resonance image, hyperbilirubinemia, brain injury

摘要: 目的 分析新生儿行为神经测定(NBNA)评分和头颅磁共振(MRI)在新生儿重度高胆红素血症脑损伤中的诊断价值。方法 选取2013年9月-2015年9月间本院收治的符合新生儿重度高胆红素血症的患儿20例为研究对象(观察组),入院后采用NBNA评分及进行头颅MRI扫描,分析MRI结果。对照组(n=20)为正常新生儿,进行NBNA评分,比较两组NBNA评分。对MRI异常组6月龄时进行复查。结果 观察组NBNA评分低于对照组。20例重度高胆红素血症患儿中,9例MRI信号异常,11例未见苍白球、丘脑信号改变,MRI异常组NBNA评分低于MRI正常组。在6月龄时复查MRI均未见异常信号。结论 在新生儿重度高胆红素血症脑损伤诊断过程中采用头颅MRI扫描具有重要作用, NBNA评分可以联合头颅MRI作为早期诊断新生儿高胆红素血症脑损伤的指标。

关键词: NBNA评分, 头颅MRI, 新生儿高胆红素血症, 脑损伤

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