Abstract: Objective To investigate the effects of exogenous pulmonary surfactant (PS) on immune function in infants with neonatal respiratory distress syndrome (NRDS),and to explore new usage of exogenous pulmonary surfactant,in order to provide new evidence and theoretical basis for prevention and treatment of neonatal respiratory distress syndrome. Method Totally 61 patients with neonatal respiratory distress syndrome were selected as the research objects. Thirty patients treated with PS were selected as the observation group, while 31 infants received no PS replacement therapy as the control group. The levels of immunoglobulin,complement and lymphocyte subtypes were measured before and after treatment in both groups. Results After treatment,the level of IgG in patients with NRDS in observation group did not significantly decrease(P>0.05),while B lymphocytes and natural killer(NK) cell increased significantly (P<0.05). However,there were no significant difference on serum IgA,IgM,complement C3,C4,Th and Ts leukomonocyte before and after treatment in the two groups(P>0.05). Conclusion Exogenous PS can improve immune function in infant with neonatal respiratory distress syndrome,and it may play a certain role in improving the therapeutic effect.

Key words: exogenous pulmonary surfactant, neonatal respiratory distress syndrome, immune function, neonates

摘要： 目的 分析外源性肺表面活性物质(PS)对新生儿呼吸窘迫综合征(NRDS)患儿免疫功能的影响,寻找外源性肺表面活性物质的新用途,为新生儿呼吸窘迫综合征防治提供新的理论依据。 方法 选择确诊为新生儿呼吸窘迫综合征的61例患儿为研究对象,以PS替代治疗者(30例)为观察组,未行PS替代治疗者(31例)为对照组,检测两组患儿治疗前后的免疫球蛋白、补体水平及淋巴细胞亚型。 结果 与治疗前比较,观察组NRDS患儿IgG水平降低不明显(P>0.05),而B细胞、NK细胞显著增高(P<0.05),而血清IgA、IgM、补体C3、C4水平及Th、Ts 淋巴细胞在治疗前后比较差异均无统计学意义(P>0.05)。结论 外源性PS可改善NRDS患儿免疫功能,对其提高疗效可能起了一定作用。

关键词: 外源性肺表面活性物质, 新生儿呼吸窘迫综合征, 免疫功能, 新生儿