Research progress on the neurobiochemical and immunological mechanism of vitamin D in tic disorders of children

doi:10.11852/zgetbjzz2020-0353

Abstract

Abstract: Besides being a nutrient and a hormone,vitamin D is a neuroactive steroid.In addition to regulating calcium and phosphorus metabolism,as well as maintaining the health of teeth and bones,vitamin D has been shown to play several important roles in extra-skeletal system,such as affecting the normal development and function of the brain,regulating immunity and affecting metabolism.In recent years,some researches have shown that serum vitamin D level in children with tic disorders (TDs) was lower than that of the healthy controls.The mechanism of vitamin D deficiency on TDs in children may involve the following aspects,changing neurotransmitter concentration and disrupting the balance between various neurotransmitters in the CBGTC pathway and effecting body's immune function.This review aims to summarize the nutritional status of vitamin D in children with TDs and the neurobiochemical and immunological mechanisms of vitamin D in TDs.

Key words: vitamin D, tic disorders, neurodevelopment, immune function

摘要： 维生素D(VD)是一种营养素,也是一种激素,还是一类神经活性甾体,除调节钙磷代谢、维持牙齿和骨骼健康外,还对骨骼外系统发挥重要作用,如影响脑部正常发育和功能、调节免疫和影响代谢等。近年来的研究表明抽动障碍(TDs)患儿血液中VD水平低于健康儿童;VD缺乏通过影响神经系统皮质-基底神经节-丘脑-皮质(CBGTC)通路中神经递质的含量、各种神经递质的平衡性以及机体免疫功能等途径在儿童TDs中发挥作用,本文对TDs儿童的VD营养状况以及VD在儿童TDs中的神经生化和免疫机制进行总结。

关键词: 维生素D, 抽动障碍, 神经发育, 免疫功能

CLC Number:

R749.94

YANG Xiao-yan, HOU Cheng, YI Ming-ji. Research progress on the neurobiochemical and immunological mechanism of vitamin D in tic disorders of children[J]. Chinese Journal of Child Health Care, 2021, 29(8): 857-860.

杨晓燕, 侯成, 衣明纪. 维生素D在儿童抽动障碍中的神经生化与免疫机制研究进展[J]. 中国儿童保健杂志, 2021, 29(8): 857-860.

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