Effect of Vitamin A supplementation on allergic disease:systematic review and meta-analysis

doi:10.11852/zgetbjzz2019-0612

Abstract

Abstract: Objective To assess the evidence of therapeutic effects of vitamin A on allergic disease. Methods Databases were searched for collecting the randomized controlled trials (RCTs) of the effects of vitamin A supplementation on allergic disease in human models from inception to September 30th,2018.Studies were critically appraised,and meta-analyses were then performed using RevMan5.3 software. Result Supplementationof vitamin A increased the risk of girls′atopy (P<0.05) and the responses of delayed-hypersensitivity (P<0.05),while significant differences were not found in wheeze or eczema between the experimental group and control group (P>0.05). Conclusion Vitamin A supplementation may increase the risk of allergy,its effect on wheeze and eczema is controversial.

Key words: vitamin A, asthma, allergy, allergic, meta-analysis

摘要： 目的系统评价维生素A补充对变应性疾病的临床作用。方法检索万方、维普、中国知网、Medline、PubMed、EBSCO等数据库,查找维生素A补充与哮喘、喘息、过敏、湿疹、肺功能等变应性疾病相关的临床随机对照试验,检索时限为建库至2018年9月30日。2位评价者按标准独立进行文献筛选、质量评价和数据提取,采用Revman 5.3软件进行Meta分析。结果维生素A补充可增加女童过敏反应发病率(P<0.05)及成人迟发型过敏反应阳性率(P<0.05),维生素A补充与儿童喘息、湿疹发病无明显相关性(P>0.05)。结论维生素A补充可能增加过敏风险,但对儿童喘息、湿疹的影响尚待明确。

关键词: 维生素A, 哮喘, 过敏, 变应性, Meta分析

CLC Number:

R725.9

CHEN Qin-zhu, XU Wang-guo. Effect of Vitamin A supplementation on allergic disease:systematic review and meta-analysis[J]. journal1, 2020, 28(2): 172-177.

陈沁竹, 徐王国. 维生素A补充与变应性疾病相关性的Meta分析[J]. 中国儿童保健杂志, 2020, 28(2): 172-177.

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