Research advances on the influence of intestinal flora on neonatal necrotizing enterocolitis

doi:10.11852/zgetbjzz2019-1531

Abstract

Abstract: Previously,neonatal necrotizing enterocolitis is considered to be related to factors such as preterm birth,hypoxia,artificial feeding,sepsis,intestinal ischemia,and intestinal pathogenic bacteria infection.In recent years,a growing number of studies have shown that intestinal flora disorders also play an important role in the pathogenesis of neonatal necrotizing enterocolitis.This article reviews the effect of intestinal flora on neonatal necrotizing enterocolitis,hoping to provide a reference for the prevention and treatment of neonatal necrotizing enterocolitis.

Key words: intestinal flora, colitis, newborn

摘要： 以前,人们认为新生儿坏死性小肠结肠炎与早产、缺氧、人工喂养、败血症、肠缺血和肠道致病菌感染等因素有关。近些年来,不断增多的研究结果显示,肠道菌群失调在新生儿坏死性小肠结肠炎的发病中也扮演重要角色。本文就肠道菌群对新生儿坏死性小肠结肠炎的影响进行综述,以期为新生儿坏死性小肠结肠炎的防治提供参考。

关键词: 肠道菌群, 结肠炎, 新生儿

CLC Number:

R722.1

WANG Zhen, YANG Shu-fen. Research advances on the influence of intestinal flora on neonatal necrotizing enterocolitis[J]. journal1, 2020, 28(11): 1231-1233.

王朕, 仰曙芬. 肠道菌群对新生儿坏死性小肠结肠炎影响的研究进展[J]. 中国儿童保健杂志, 2020, 28(11): 1231-1233.

References

[1] Xiang L,Peng L,Du W,et al.Protective effects of bifidobacterium on intestinal barrier function in LPS-induced enterocyte barrier injury of caco-2 monolayers and in a rat NEC model[J].PLoS One,2016,11(8):e0161635.
[2] Hackam DJ,Good M,Sodhi CP.Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis:Toll-like receptors throw the switch[J].Semin Pediatr Surg,2013,22(2):76-82.
[3] Lu P,Sodhi CP,Hackam DJ.Toll-like receptor regulation of intestinal development and inflammation in the pathogenesis of necrotizing enterocolitis[J].Pathophysiology,2014,21(1):81-93.
[4] Frosali S,Pagliari D,Gambassi G,et al.How the intricate interaction among Toll-like receptors,microbiota,and intestinal immunity can influence gastrointestinal pathology[J].J Immunol Res,2015,2015:489821.
[5] Erika C.Neonatal necrotizing enterocolitis inflammation and intestinal immaturity[J].Antiinflamm Antiallergy Agents Med Chem,2009,8(3):248-259.
[6] Borthakur A,Bhattacharyya S,Alrefai WA,et al.Platelet activating factor induced NF kappa-B activation and IL-8 production in intestinal epithelial cells are Bcl10-dependent[J].Inflamnl Bowel Dis,2010,16 (4):593-603.
[7] Markel TA,Crisostomo PR,Wang M,et al.Activation of individual tumor necrosis factor receptors differentially affects stem cell growth factor and cytokine production[J].Am J Physiol Gastrointest Liver Physiol,2007,293(4):657-662.
[8] Cuna A,Sampath V.Genetic alterations in necrotizing enterocolitis[J].Semin Perinatol,2016,41(1):61-69.
[9] Munyaka PM,Khafipour E,Ghia JE.External influence of early childhood establishment of gut microbiota and subsequent health implications[J].Front Pediatr,2014,2:109.
[10] Rutayisire E,Huang K,Liu Y,et al.The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants' life:a systematic review[J].BMC Gastroenterol,2016,16(1):86.
[11] O'Sullivan A,Farver M,Smilowitz JT.The influence of early infant feeding practices on the intestinal microbiome and body composition in infants[J].Nutr Metab Insights,2015,8(Suppl 1):1-9.
[12] Arrieta MC,Stiemsma LT,Amenyogbe N,et al.The intestinal microbiome in early life:health and disease[J].Front Immunol,2014,5(5):427.
[13] Greenwood C,Morrow AL,Lagomarcino AJ,et al.Early empiric antibiotic use in preterm infants is associated with lower bacterial diversity and higher relative abundance of enterobacter[J].J Pediatr,2014,165(1):23-29.
[14] 许巍.坏死性小肠结肠炎的早产儿存在肠道微生物菌群不平衡[J].国际儿科学杂志,2018,45(1):72-72.
[15] Stewart CJ,Embleton ND,Marrs EC,et al.Temporal bacterial and metabolic development of the preterm gut reveals specific signatures in health and disease[J].Microbiome,2016,4(1):67.
[16] Volker M,Michael YC,Maria U,et al.Fecal microbiota in premature infants prior to necrotizing enterocolitis[J].PLoS One,2011,6(6):e20647.
[17] Warner BB,Deych E,Zhou Y,et al.Gut bacteria dysbiosis and necrotizing enterocolitis in very low birth weight infants:a prospective case-control study[J].Lancet,2016,387(10031):1928-1936.
[18] Stewart CJ,Marrs EC,Nelson A,et al.Development of the preterm gut microbiome in twins at risk of necrotizing enterocolitis and sepsis[J].PLoS One,2013,8(8):e73465.
[19] Cassir N,Simeoni U,La Scola B.Gut microbiota and the pathogenesis of necrotizing enterocolitis in preterm neonates[J].Future Microbiol,2016,11(2):273-292.
[20] 曾凌空,张卫红,张振,等.NEC早产儿肠道菌群的变化趋势[C].长沙:中华医学会全国儿科学术会议,2013.
[21] 李阳,佘加林,艾青,等.早产儿坏死性小肠结肠炎肠道茵群多样性及其动态研究[J].中国编证儿科杂志,2014,9(2):117-121.
[22] Alfaleh K,Anabrees J.Probiotics for prevention of necrotizing enterocolitis in preterm infants[M].The Cochrane Library.John Wiley & Sons,Ltd,2014.
[23] Lau CS,Chamberlain RS.Probiotic administration can prevent necrotizing enterocolitis in preterm infants:a meta-analysis[J].J Pediatr Surg,2015,50(8):1405-1412.
[24] 黄玉萍,王艳丽,叶秀桢,等.益生菌对早产儿生后不同时期肠道菌群的影响[J].国际医药卫生导报,2019,25(7):1092-1095.
[25] Costeloe K,Hardy P,Juszczak E,et al.Bifidobacterium bre ve BBG-001 in very preterm infants:a randomised controlled phase 3 trial[J].Lancet,2016,387(10019):649-660.
[26] Srinivasjois R,Rao S,Patole S.Prebiotic supplementation in preterm neonates:updated systematic review and meta-analysis of randomised controlled trials[J].Clin Nutr,2013,32(6):958-965.
[27] Wu SF,Caplan M,Lin HC.Necrotizing enterocolitis:old pro blem with new hope[J].Pediatr Neonatol,2012,53(3):158-63.