Research advance in the relationship between hyperoxia and immature brain injury

doi:10.11852/zgetbjzz2023-0268

Abstract

Abstract: With significant progress being made in neonatal intensive care, the survival rate of premature infants has been substantially increased. Hyperoxia therapy plays a key role in the early treatment of neonates, especially in premature infants. However, supraphysiological concentration of oxygen has toxic effects on the developing lung and retina. Moreover, permanent neurological impairments caused by oxidative stress induced by hyperoxia have been paid more and more attention, especially in premature infants with incomplete brain development, which brings heavy burden to children and their families. This article reviews the mechanism of hyperoxia on immature brain injury and its potential treatment strategies.

Key words: hyperoxia, oxidative stress, brain injury, neonate

摘要： 随着新生儿重症监护取得巨大进展,早产儿的存活率明显提高,高氧治疗在新生儿尤其是在早产儿早期治疗中发挥着关键的作用,但超生理浓度的氧对发育中的肺和视网膜都有着严重危害。不仅如此,在临床及实验工作中,高氧引起的氧化应激状态导致的永久性神经损伤逐渐被重视,尤其是在脑发育尚不完全的早产儿中,这种损害给患儿及其家庭带来沉重的负担。本文就高氧对未成熟脑的损伤机制及其潜在治疗策略进行综述。

关键词: 高氧, 氧化应激, 脑损伤, 新生儿

CLC Number:

R722

WU Tong, JI Hong. Research advance in the relationship between hyperoxia and immature brain injury[J]. Chinese Journal of Child Health Care, 2023, 31(11): 1214-1218.

武童, 冀红. 高氧与未成熟脑损伤的研究进展[J]. 中国儿童保健杂志, 2023, 31(11): 1214-1218.

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