比阿培南在老年患者中的合理应用及疗效评价

中国临床药理学与治疗学 ›› 2015, Vol. 20 ›› Issue (1): 43-46.

比阿培南在老年患者中的合理应用及疗效评价

李运曼, Kodithuwakku Nandani Darshika, 方伟蓉

中国药科大学生理教研室,南京 210009,江苏

收稿日期:2013-07-27 修回日期:2014-02-12 发布日期:2020-07-20
通讯作者: 方伟蓉,通信作者,女,博士,副教授,硕士生导师,主要从事心脑血管药理研究。Tel:025-83271173 E-mail:weirongfang@163.com
作者简介:李运曼,女,博士,教授,博士生导师,主要从事心脑血管药理及肿瘤多药耐药逆转研究。

Rational medication and therapeutic evaluation of Biapenem in the elderly population

LI Yun-man, Kodithuwakku Nandani Darshika, FANG Wei-rong

Department of Physiology, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China

Received:2013-07-27 Revised:2014-02-12 Published:2020-07-20

摘要/Abstract

摘要： 比阿培南是新型1β-甲基碳青霉烯类抗生素,但说明书中并未明确老年患者如何用药。本文主要综述药物在老年人体内的代谢特点、比阿培南在老年患者体内的代谢动力学特征以及临床疗效和不良反应,为老年患者合理应用比阿培南提供依据。比阿培南在老年患者体内的代谢动力学参数如血浆药物浓度时间曲线、尿中原形累积排泄率及半衰期与年轻患者无明显差异,仅总清除率和肾脏清除率呈年龄相关性下降。因此,比阿培南应用于中、重度感染老年患者,在肾功能随年龄正常下降时无需调整给药剂量,而当肾功能严重衰竭(肌酐清除率<21.1 mL/min)时应酌情减量。

关键词: 比阿培南, 老年人, 代谢动力学, 合理用药

Abstract: Biapenem is a comparatively new kind of 1β-methyl carbapenem antibiotic, of which the specification of drug application in the elderly is not yet fully discovered. This review is designed to summarize drug metabolism in elderly population. Furthermore, we sum up pharmacokinetic characteristics, clinical efficacy and adverse reactions of biapenem in the elderly. Pharmacokinetic studies of biapenem in the elderly found that its prototype accumulation in the plasma drug concentration-versus-time curve, urinary excretion rate, and half-life of the drug had no significance difference as compared to young people. Only the total body clearance and renal clearance rate showed an age-related decline. For older patients with severe infections, based on the normal renal function with senility, dosage adjustment of biapenem is not essential. Biapenem is recommended to reduce dosage in elderly with severe renal failure (Creatinine clearance rate <21.1 mL/min).

Key words: biapenem, the elderly, pharmacokinetics, rational drug usage

中图分类号:

R978

李运曼, Kodithuwakku Nandani Darshika, 方伟蓉. 比阿培南在老年患者中的合理应用及疗效评价[J]. 中国临床药理学与治疗学, 2015, 20(1): 43-46.

LI Yun-man, Kodithuwakku Nandani Darshika, FANG Wei-rong. Rational medication and therapeutic evaluation of Biapenem in the elderly population[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(1): 43-46.

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