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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2018, Vol. 23 ›› Issue (10): 1188-1195.doi: 10.12092/j.issn.1009-2501.2018.10.016

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Hepatic macrophages in liver injury and repair

WANG Lu 1, LI Liping 1, XING Xin 1, XU Dengqiu 1, XIAO Li 2, JIANG Zhenzhou 1,3,4, ZHANG Luyong 1,5, SUN Lixin 1,3,4   

  1. 1 Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, Jiangsu, China; 2 College of Life Science, Huzhou University, Huzhou 313000, Zhejiang, China; 3 Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, Jiangsu, China; 4 Jiangsu Center for Pharmacodynamics Researchand Evaluation, China Pharmaceutical University, Nanjing 210009, Jiangsu, China; 5 Center for Drug Screening and Pharmacodynamics Evaluation, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China
  • Received:2018-03-30 Revised:2018-04-19 Online:2018-10-26 Published:2018-10-25

Abstract:

Hepatic macrophages play a critical role in the pathogenesis of liver injury and repair. It is noted that, based on the distinct origins and phenotypes, hepatic macrophages can clear bacterial pathogens, antigens, promote or inhibit the liver inflammation, which directly participate in the liver disease development and repair. This article reviews the functions and phenotypes of hepatic macrophages, and their roles in the different stages of liver injury and repair. Also, the potential macrophage-targeted therapies against liver diseases were also summarized.

Key words: hepatic macrophages, liver injury, liver repair, immunity

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