Protective effects of Ferulic acid on acute liver injury induced by D-GalN/LPS in mice

doi:10.12092/j.issn.1009-2501.2018.12.003

Abstract

Abstract:

AIM:To study the protective effects of Ferulic acid on acute liver injury induced by D-GalN/LPS in mice. METHODS:A total of 60 BALB/c mice were divided into six groups：control group，D-galactosamine/lipopolysaccharide(D-GalN/LPS) model group(600 mg·30 μg/kg)，bifendate group（200 mg/kg），the high，middle and low dose groups of Ferulic acid （30, 15, 7.5 mg/kg, respectively）, with 10 mice in each group. All groups received intragastric administration once a day for 21 days. Mice were sacrificed 2 h after the last administration to collect liver tissue and blood from eyeball, and ALT, AST, SOD, GSH-Px, MDA were detected. The pathological changes of liver tissue were observed, and liver index was calculated according to the body weight of mice.RESULTS:Compared with D-GalN/LPS model group, bifendate group（200 mg/kg） and the high, middle and low dose groups of Ferulic acid presented siginificant decrease of the liver index, serum ALT, AST and MDA (P<0.05), and significant increase of SOD and GSH-Px (P<0.05). Pathological analysis of the liver tissue showed that bifendate and different doses of Ferulic acid could alleviate the hepatocytosis and necrosis. CONCLUSION: Ferulic acid has protective effect on acute liver injury induced by D-GalN/LPS in mice. The mechanism maybe related to the anti-oxidation effect of Ferulic acid.

Key words: Ferulic acid, lipopolysaccharide, acute liver injury, anti-oxidation

CLC Number:

R965.2
R33

ZHONG Zhengling，ZHANG Fei，JIANG Yuhua，ZHANG Weiting，TONG Jiucui，LI Juan，CHU Jiru，XIE Haitang. Protective effects of Ferulic acid on acute liver injury induced by D-GalN/LPS in mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(12): 1335-1339.

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