Abstract: AIM: To observe the therapeutic effect of HFMD combine with encephalitis by monosialoteterahexosyl ganglioside (GM-1). METHODS: 139 cases in our hospital from April 2010 to November 2010 were randomly divided into two groups,one with 81 cases as a treatment group and another with 58 cases as control group. All of the two groups were accepted the treatment of GG＋MePr＋MNT+ FSM i.v. within antiviral therapy. The treatment group was added ivgtt of the 5%GS 50 mL with GM-1 20 mg, 10-14 days as one course of treatment. RESULTS: The times of Symptoms improved after treatment, including muscle tension, startle, lethargy, vomiting of treatment group were (8.0±3.2),(4.2±1.0),(3.6±1.3),(2.8±0.8) d, control group were (10.3±3.8),(4.8±1.3),(4.2±1.3),(3.2±1.0) d, each indicator had statistically significant difference (P<0.05). In treatment group,excellence 43 cases, utility 29 cases, ineffective 9 cases,the total effective rate was 88.89%.In control group, excellence 21 cases, utility 22 cases, ineffective 15 cases,the total efficiency rate was 74.14%.The trerapeutic effect of treatment group was better than that of control group (P<0.05). CONCLUSION: GM-1 can rapidly relieve the clinical symptoms, improve the recovery rate, and has no significant adverse reactions, is safe and effective.

Key words: GM-1, HFMD, Encephalitis