关键词: 过敏性紫癜, 细胞凋亡, 细胞因子, 单个核细胞

Abstract: 【Objective】 To observe the changes of mononuclear cell (MNCs) apoptosis and the level of inflammatory cytokines and IGF-1 in patients with henoch-schonlein purpura (HSP), and to study the relationship between them. 【Methods】 The apoptosis of MNCs in 36 patients with HSP and 22 healthy controls were determined with flow cytometry. The inflammatory cytokines and theIGF-1 were tested with ELISA method. 【Results】 The percentage of MNCs apoptosis in the patients with HSP was significantly higher than that of healthy controls. The levels of IL-8, TNF-α, IL-6, IGF-1 in patients with HSP were significantly higher than those of healthy controls, and the increased levels of inflammatory cytokines and IGF-1 in HSP patients were positively correlated to the percentage of MNCs apoptosis. 【Conclusions】 The data demonstrates that there is a promote apoptotic process of MNCs in active HSP. The high expression of inflammatory cytokines and IGF-1 may play an important role of promoting MNCs apoptosis which reduces the functional life span of MNCs. For this reason, modulating the expression of cytokines, IGF-1 and moderately controlling the apoptosis of MNCs may be a new therapeutic target for HSP treatment.

Key words: henoch-schonlein purpura, apoptosis, cytokines, mononuclear cell