关键词: 孤独症谱系障碍, 炎症, 细胞因子, 精神发育迟滞

Abstract: Objective To study the correlation between inflammatory cytokines and autism spectrum disorder (ASD),and to identify serum markers for diagnosis and treatment of ASD. Methods A total of 70 ASD patients and 70 normal control children in Zhuhai Municipal Maternal and Child Health Care Hospital were enrolled in this study from June 2015 to May 2017.And 11 kinds of inflammatory cytokines such as GM-CSF,IL-5,IL-13,MIG,MIP-1α,MIP-1β,PDGF- BB,RANTES,TIMP-1,TIMP-2 and TNF RⅡ in serum samples from were tested by protein chip technology were tested. Results There were significant differences on the levels of GM-CSF,IL-5,IL-13,MIG and MIP-1α between the case group and control group (t=4.857,2.364,4.024,2.209,-5.054,all P<0.05).The levels of GM-CSF,IL-5,IL-13 and MIG in the case group were higher than those in the control group,while the level of MIP-1α was lower in the case group.Also,the level of MIP-1α was associated with mental retardation in ASD children. Conclusions Increased levels of serum GM-CSF,IL-5,IL-13,MIG and decreased MIP-1α are associated with the pathogenesis of ASD.And low level of MIP-1α is closely linked with mental retardation in children with ASD.This conclusion provides the scientific basis for early intervention in ASD children from neuro-immunology point of view.

Key words: autism spectrum disorder, inflammation, cytokines, mental retardation