[1]Ng SC, Shi HY, HAMIDI N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies[J]. Lancet, 2018, 390(10114): 2769-2778.
[2]Macias-Ceja DC, Cosin-Roger J, Ortiz-Masia D, et al. Stimulation of autophagy prevents intestinal mucosal inflammation and ameliorates murine colitis[J]. Br J Pharmacol, 2017, 174(15): 2501-2511.
[3]Saitoh T, Fujita N, Jang M H, et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production[J]. Nature, 2008, 456(7219): 264-268.
[4]Law BY, Mok SW, Wu AG, et al. New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy[J]. Molecules, 2016, 21(3): 359.
[5]Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)[J]. Autophagy, 2016, 12(1): 1-222.
[6]Baxt LA, Xavier RJ. Role of Autophagy in the Maintenance of Intestinal Homeostasis[J]. Gastroenterology, 2015, 149(3): 553-562.
[7]Ichimura Y, Kumanomidou T, Sou YS, et al. Structural basis for sorting mechanism of p62 in selective autophagy[J]. J Biol Chem, 2008, 283(33): 22847-22857.
[8]Levine B, Kroemer G. Autophagy in the pathogenesis of disease[J]. Cell, 2008, 132(1): 27-42.
[9]Nguyen HT, Lapaquette P, Bringer MA, et al. Autophagy and Crohn's disease[J]. J Innate Immun, 2013, 5(5): 434-443.
[10]Hooper KM, Barlow PG, Stevens C, et al. Inflammatory Bowel Disease Drugs: A Focus on Autophagy[J]. J Crohns Colitis, 2017, 11(1): 118-127.
[11]Pott J, Maloy KJ. Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis[J]. Autophagy, 2018, 14(8): 1460-1461.
[12]Cooney R, Baker J, Brain O, et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation[J]. Nat Med, 2010, 16(1): 90-97.
[13]Pott J, Kabat AM, Maloy KJ. Intestinal Epithelial Cell Autophagy Is Required to Protect against TNF-Induced Apoptosis during Chronic Colitis in Mice[J]. Cell Host Microbe, 2018, 23(2): 191-202.e4.
[14]Homer CR, Richmond AL, Rebert NA, et al. ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis[J]. Gastroenterology, 2010, 139(5): 1630-1641, 41.e1-2.
[15]Cadwell K, Liu JY, Brown SL, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells[J]. Nature, 2008, 456(7219): 259-263.
[16]Thachil E, Hugot JP, Arbeille B, et al. Abnormal activation of autophagy-induced crinophagy in Paneth cells from patients with Crohn's disease[J]. Gastroenterology, 2012, 142(5): 1097-1099 e4.
[17]张琮, 王嘉正, 沈玉洁, 等. 自噬诱导剂pp242对肿瘤坏死因子-α所致肠屏障损伤的影响[J]. 胃肠病学, 2017, 22(6): 337-340.
[18]Nguyen HT, Dalmasso G, Muller S, et al. Crohn's disease-associated adherent invasive Escherichia coli modulate levels of microRNAs in intestinal epithelial cells to reduce autophagy[J]. Gastroenterology, 2014, 146(2): 508-519.
[19]Cosin-Roger J, Simmen S, Melhem H, et al. Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation[J]. Nat Commun, 2017, 8(1): 98.
[20]Munz C. Enhancing immunity through autophagy[J]. Annu Rev Immunol, 2009, 27:423-449.
[21]Salio M, Puleston DJ, Mathan TS, et al. Essential role for autophagy during invariant NKT cell development[J]. Proc Natl Acad Sci U S A, 2014, 111(52): E5678-5687.
[22]Parekh VV, Wu L, Boyd KL, et al. Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of Vps34[J]. J Immunol, 2013, 190(10): 5086-5101.
[23]Lee H Y, Kim J, Quan W, et al. Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis[J]. Autophagy, 2016, 12(8): 1390-1403.
[24]许昌泰, 郭学刚, 潘伯荣. 炎症性肠病研究现状[J]. 天津医药, 2002, 30(6): 382-384.
[25]张兰兰, 牛润章, 司依馨. 炎症性肠病的研究现状[J]. 中国实用内科杂志, 2012, (s2): 42-45.
[26]Feuerstein JD, Cheifetz AS. Ulcerative colitis: epidemiology, diagnosis, and management[J]. Mayo Clin Proc, 2014, 89(11): 1553-1563.
[27]李军祥, 谭祥, 毛堂友. 溃疡性结肠炎中西医结合治疗策略[J]. 中国中西医结合杂志, 2017, 37(4): 398-400.
[28]Ko JK, Chik CW. The protective action of radix Astragalus membranaceus against hapten-induced colitis through modulation of cytokines[J]. Cytokine, 2009, 47(2): 85-90.
[29]Meng Q, Du X, Wang H, et al. Astragalus polysaccharides inhibits cell growth and pro-inflammatory response in IL-1beta-stimulated fibroblast-like synoviocytes by enhancement of autophagy via PI3K/AKT/mTOR inhibition[J]. Apoptosis, 2017, 22(9): 1138-1146.
[30]Liu C, Wang J, Yang Y, et al. Ginsenoside Rd ameliorates colitis by inducing p62-driven mitophagy-mediated NLRP3 inflammasome inactivation in mice[J]. Biochem Pharmacol, 2018, 155:366-379.
[31]Han KH, Park JM, Jeong M, et al. Heme Oxygenase-1 Induction and Anti-inflammatory Actions ofAtractylodes macrocephalaandTaraxacum herba Extracts Prevented Colitis and Was More Effective than Sulfasalazine in Preventing Relapse[J]. Gut Liver, 2017, 11(5): 655-666.
[32]Liu X, Yu X, Xu X, et al. The protective effects of Poria cocos-derived polysaccharide CMP33 against IBD in mice and its molecular mechanism[J]. Food Funct, 2018, 9(11): 5936-5949.
[33] Lee SG, Kim MM. Pachymic acid promotes induction of autophagy related to IGF-1 signaling pathway in WI-38 cells[J]. Phytomedicine, 2017, 36:82-87.
[34]Lim SM, Jeong JJ, Kang GD, et al. Timosaponin AIII and its metabolite sarsasapogenin ameliorate colitis in mice by inhibiting NF-kappaB and MAPK activation and restoring Th17/Treg cell balance[J]. Int Immunopharmacol, 2015, 25(2): 493-503.
[35]Sy LK, Yan SC, Lok CN, et al. Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells[J]. Cancer Res, 2008, 68(24): 10229-10237.
[36]Wang Y, Liu Y, Hu Y. Optimization of polysaccharides extraction from Trametes robiniophila and its antioxidant activities[J]. Carbohydr Polym, 2014, 111:324-332.
[37]Jing Y, Li A, Liu Z, et al. Absorption of Codonopsis pilosula Saponins by Coexisting Polysaccharides Alleviates Gut Microbial Dysbiosis with Dextran Sulfate Sodium-Induced Colitis in Model Mice[J]. Biomed Res Int, 2018, 2018:1781036.
[38]Huo J, Qin F, Cai X, et al. Chinese medicine formula "Weikang Keli" induces autophagic cell death on human gastric cancer cell line SGC-7901[J]. Phytomedicine, 2013, 20(2): 159-165.
[39]Liu W, Liu Y, Wang Z, et al. Suppression of MAPK and NF-kappa B pathways by schisandrin B contributes to attenuation of DSS-induced mice model of inflammatory bowel disease[J]. Pharmazie, 2015, 70(9): 598-603.
[40]Lai Q, Wei J, Mahmoodurrahman M, et al. Pharmacokinetic and nephroprotective benefits of using Schisandra chinensis extracts in a cyclosporine A-based immune-suppressive regime[J]. Drug Des Devel Ther, 2015, 9:4997-5018.
[41]Lu Y, Zhu M, Chen W, et al. Tetramethylpyrazine improves oxazolone-induced colitis by inhibiting the NF-kappaB pathway[J]. Clin Invest Med, 2014, 37(1): E1-9.
[42]Gong X, Ivanov VN, Davidson MM, et al. Tetramethylpyrazine (TMP) protects against sodium arsenite-induced nephrotoxicity by suppressing ROS production, mitochondrial dysfunction, pro-inflammatory signaling pathways and programed cell death[J]. Arch Toxicol, 2015, 89(7): 1057-1070.
[43]Wong VK, Yu L, Cho CH. Protective effect of polysaccharides from Angelica sinensis on ulcerative colitis in rats[J]. Inflammopharmacology, 2008, 16(4): 162-167.
[44]Shi Y, Xiao L, Yin Y, et al. Ligustilide inhibits tumour necrosis factor-alpha-induced autophagy during C2C12 cells differentiation[J]. Biomed Pharmacother, 2015, 69:42-46.
[45]Wang S, Tao P, Zhao L, et al. Panax notoginseng Promotes Repair of Colonic Microvascular Injury in Sprague-Dawley Rats with Experimental Colitis[J]. Evid Based Complement Alternat Med, 2018, 2018:4386571.
[46]Liu XW, Lu MK, Zhong HT, et al. Panax Notoginseng Saponins Attenuate Myocardial Ischemia Reperfusion Injury via the HIF-1alpha/BNIP3 Pathway of Autophagy[J]. J Cardiovasc Pharmacol, 2019,73(2):92-99.
[47]Johari SMP, Joshi CP, Gandhi TMP. Effect of Cyperus Rotundus on Cytokine Gene Expression in Experimental Inflammatory Bowel Disease[J]. Iran J Med Sci, 2016, 41(5): 391-398.
[48]Wen XD, Wang CZ, Yu C, et al. Salvia miltiorrhiza (dan shen) significantly ameliorates colon inflammation in dextran sulfate sodium induced colitis[J]. Am J Chin Med, 2013, 41(5): 1097-1108.
[49]Jing Z, Fei W, Zhou J, et al. Salvianolic acid B, a novel autophagy inducer, exerts antitumor activity as a single agent in colorectal cancer cells[J]. Oncotarget, 2016, 7(38): 61509-61519.
[50]Cheng H, Xia B, Zhang L, et al. Matrine improves 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice[J]. Pharmacol Res, 2006, 53(3): 202-208.
[51]Yang J, Yao S. JNK-Bcl-2/Bcl-xL-Bax/Bak Pathway Mediates the Crosstalk between Matrine-Induced Autophagy and Apoptosis via Interplay with Beclin 1[J]. Int J Mol Sci, 2015, 16(10): 25744-25758.
[52]Liu Y, Liu X, Hua W, et al. Berberine inhibits macrophage M1 polarization via AKT1/SOCS1/NF-kappaB signaling pathway to protect against DSS-induced colitis[J]. Int Immunopharmacol, 2018, 57:121-131.
[53]Zhou H, Feng L, Xu F, et al. Berberine inhibits palmitate-induced NLRP3 inflammasome activation by triggering autophagy in macrophages: A new mechanism linking berberine to insulin resistance improvement[J]. Biomed Pharmacother, 2017, 89:864-874.
[54]Gu P, Zhu L, Liu Y, et al. Protective effects of paeoniflorin on TNBS-induced ulcerative colitis through inhibiting NF-kappaB pathway and apoptosis in mice[J]. Int Immunopharmacol, 2017, 50:152-160.
[55]Cao BY, Yang YP, Luo WF, et al. Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway[J]. J Ethnopharmacol, 2010, 131(1): 122-129.
[56]Zhao J, Sun Y, Shi P, et al. Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy[J]. Int Immunopharmacol, 2015, 26(1): 221-228.
[57]Huo X, Liu D, Gao L, et al. Flavonoids Extracted from Licorice Prevents Colitis-Associated Carcinogenesis in AOM/DSS Mouse Model[J]. Int J Mol Sci, 2016, 17(9): pii: E1343.
[58]Tsai JP, Lee CH, Ying TH, et al. Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells[J]. Oncotarget, 2015, 6(30): 28851-28866.
[59]Zhang YS, Wang F, Cui SX, et al. Natural dietary compound naringin prevents azoxymethane/dextran sodium sulfate-induced chronic colorectal inflammation and carcinogenesis in mice[J]. Cancer Biol Ther, 2018, 19(8): 735-744.
[60]Wang X, Fan F, Cao Q. Modified Pulsatilla decoction attenuates oxazolone-induced colitis in mice through suppression of inflammation and epithelial barrier disruption[J]. Mol Med Rep, 2016, 14(2): 1173-1179.
[61]Zhang Y, Bao J, Wang K, et al. Pulsatilla Saponin D Inhibits Autophagic Flux and Synergistically Enhances the Anticancer Activity of Chemotherapeutic Agents Against HeLa Cells[J]. Am J Chin Med, 2015, 43(8): 1657-1670.
[62]Wang S, Zhang Y, Saas P, et al. Oridonin's therapeutic effect: suppressing Th1/Th17 simultaneously in a mouse model of Crohn's disease[J]. J Gastroenterol Hepatol, 2015, 30(3): 504-512.
[63]Kang N, Cao SJ, Zhou Y, et al. Inhibition of caspase-9 by oridonin, a diterpenoid isolated from Rabdosia rubescens, augments apoptosis in human laryngeal cancer cells[J]. Int J Oncol, 2015, 47(6): 2045-2056.
[64]Choi YA, Kang OH, Park HJ, et al. Effect of processed Scutellaria baicalensis on dextran sulfate sodium-induced colitis in mice[J]. Int J Mol Med, 2005, 16(4): 667-672.
[65]Feng Q, Wang H, Pang J, et al. Prevention of Wogonin on Colorectal Cancer Tumorigenesis by Regulating p53 Nuclear Translocation[J]. Front Pharmacol, 2018, 9:1356.
[66]Yoo HS, Kim JM, Jo E, et al. Modified Panax ginseng extract regulates autophagy by AMPK signaling in A549 human lung cancer cells[J]. Oncol Rep, 2017, 37(6): 3287-3296.
[67]Chen Z, Lu T, Yue X, et al. Neuroprotective effect of ginsenoside Rb1 on glutamate-induced neurotoxicity: with emphasis on autophagy[J]. Neurosci Lett, 2010, 482(3): 264-268.
[68]Hong H, Cui CH, Kim JK, et al. Enzymatic Biotransformation of Ginsenoside Rb1 and Gypenoside XVII into Ginsenosides Rd and F2 by Recombinant beta-glucosidase from Flavobacterium johnsoniae[J]. J Ginseng Res, 2012, 36(4): 418-424.
[69]Mai T4 T, Moon J, Song Y, et al. Ginsenoside F2 induces apoptosis accompanied by protective autophagy in breast cancer stem cells[J]. Cancer Lett, 2012, 321(2): 144-153.
[70]Ko JK, Lam FY, Cheung AP. Amelioration of experimental colitis by Astragalus membranaceus through anti-oxidation and inhibition of adhesion molecule synthesis[J]. World J Gastroenterol, 2005, 11(37): 5787-5794.
[71]Dong Z, Zhou J, Zhang Y, et al. Astragaloside-IV Alleviates Heat-Induced Inflammation by Inhibiting Endoplasmic Reticulum Stress and Autophagy[J]. Cell Physiol Biochem, 2017, 42(2): 824-837.
[72]Lai Q, Luo Z, Wu C, et al. Attenuation of cyclosporine A induced nephrotoxicity by schisandrin B through suppression of oxidative stress, apoptosis and autophagy[J]. Int Immunopharmacol, 2017, 52:15-23.
[73]Han KH, Park JM, Jeong M, et al. Heme Oxygenase-1 Induction and Anti-inflammatory Actions of Atractylodes macrocephala and Taraxacum herba Extracts Prevented Colitis and Was More Effective than Sulfasalazine in Preventing Relapse[J]. Gut Liver, 2017, 11(5): 655-666.
[74]Dai YC, Zheng L, Zhang YL, et al. Effects of Jianpi Qingchang decoction on the quality of life of patients with ulcerative colitis: A randomized controlled trial[J]. Medicine (Baltimore), 2017, 96(16): e6651.
[75]Dai YC, Zheng L, Zhang YL, et al. Jianpi Qingchang decoction regulates intestinal motility of dextran sulfate sodium-induced colitis through reducing autophagy of interstitial cells of Cajal[J]. World J Gastroenterol, 2017, 23(26): 4724-4734.
[76] Zhang WF, Yang Y, Su X, et al. Deoxyschizandrin suppresses dss-induced ulcerative colitis in mice[J]. Saudi J Gastroenterol, 2016, 22(6): 448-455.
[77]Kim JS, Yi HK. Schisandrin C enhances mitochondrial biogenesis and autophagy in C2C12 skeletal muscle cells: potential involvement of anti-oxidative mechanisms[J]. Naunyn Schmiedebergs Arch Pharmacol, 2018, 391(2): 197-206.
[78]Hou YZ, Zhao GR, Yuan YJ, et al. Inhibition of rat vascular smooth muscle cell proliferation by extract of Ligusticum chuanxiong and Angelica sinensis[J]. J Ethnopharmacol, 2005, 100(1/2): 140-144.
[79]Shan CS, Xu QQ, Shi YH, et al. Chuanxiong Formulae for Migraine: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials[J]. Front Pharmacol, 2018, 9:589.
[80]Li Y, Xu C, Zhang Q, et al. In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases[J]. J Ethnopharmacol, 2005, 98(3): 329-333.
[81]Cao J, Miao Q, Miao S, et al. Tetramethylpyrazine (TMP) exerts antitumor effects by inducing apoptosis and autophagy in hepatocellular carcinoma[J]. Int Immunopharmacol, 2015, 26(1): 212-220.
[82]Wang K, Yang Q, Ma Q, et al. Protective Effects of Salvianolic Acid A against Dextran Sodium Sulfate-Induced Acute Colitis in Rats[J]. Nutrients, 2018, 10(6): pii: E791.
[83]Yang Y, Chen G, Yang Q, et al. Gut microbiota drives the attenuation of dextran sulphate sodium-induced colitis by Huangqin decoction[J]. Oncotarget, 2017, 8(30): 48863-48874.
[84]Kim DH, Hossain MA, Kang YJ, et al. Baicalein, an active component of Scutellaria baicalensis Georgi, induces apoptosis in human colon cancer cells and prevents AOM/DSS-induced colon cancer in mice[J]. Int J Oncol, 2013, 43(5): 1652-1658.
[85]Kuang L, Cao X, Lu Z. Baicalein Protects against Rotenone-Induced Neurotoxicity through Induction of Autophagy[J]. Biol Pharm Bull, 2017, 40(9): 1537-1543.
[86]Tsai CF, Yeh WL, Huang SM, et al. Wogonin induces reactive oxygen species production and cell apoptosis in human glioma cancer cells[J]. Int J Mol Sci, 2012, 13(8): 9877-9892.
[87]Xu S, Zhao X, Zhao Q, et al. Wogonin prevents rat dorsal root ganglion neurons death via inhibiting tunicamycin-induced ER stress in vitro[J]. Cell Mol Neurobiol, 2015, 35(3): 389-398.
[88]Zhang Q, Piao XL, Piao XS, et al. Preventive effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharides[J]. Food Chem Toxicol, 2011, 49(1): 61-69.
[89]Yang LQ, Singh M, Yap EH, et al. In vitro response of Blastocystis hominis against traditional Chinese medicine[J]. J Ethnopharmacol, 1996, 55(1): 35-42.
[90]Tong Y, Ip S, Lao L, et al. Analgesic effect of Coptis chinensis rhizomes (Coptidis Rhizoma) extract on rat model of irritable bowel syndrome[J]. J Ethnopharmacol, 2011, 135(3): 754-761.
[91]Fan X, Wang J, Hou J, et al. Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway[J]. J Transl Med, 2015, 13:92.
[92]Jeong HW, Hsu KC, Lee JW, et al. Berberine suppresses proinflammatory responses through AMPK activation in macrophages[J]. Am J Physiol Endocrinol Metab, 2009, 296(4): E955-964.
[93]Yo YT, Shieh GS, Hsu KF, et al. Licorice and licochalcone-A induce autophagy in LNCaP prostate cancer cells by suppression of Bcl-2 expression and the mTOR pathway[J]. J Agric Food Chem, 2009, 57(18): 8266-8273. |