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中国临床药理学与治疗学 ›› 2023, Vol. 28 ›› Issue (5): 583-593.doi: 10.12092/j.issn.1009-2501.2023.05.014

• 综述与讲座 • 上一篇    下一篇

基于多种化疗肠损伤发生机制的中医药防治进展

李 爽1,2,韩淑贞3,4,戴瑜婷5,修明慧1,3,5,杜籼芹1,2,和建政1,3,4,蔺兴遥1,2   

  1. 1甘肃中医药大学,敦煌医学与转化教育部重点实验室,兰州  730000,甘肃;2甘肃中医药大学,甘肃中医药研究中心,兰州  730000,甘肃;3甘肃中医药大学,甘肃省高校重大疾病分子医学与中医药防治研究重点实验室,兰州  730000,甘肃;4甘肃中医药大学,基础医学院,兰州  730000,甘肃;5甘肃中医药大学,公共卫生学院,兰州  730000,甘肃
  • 收稿日期:2022-11-21 修回日期:2023-04-18 出版日期:2023-05-26 发布日期:2023-06-08
  • 通讯作者: 和建政,男,博士后,副教授,硕士生导师,从事中西医结合防治慢性疾病的相关研究。 E-mail: hejianzheng1006@163.com 蔺兴遥,男,硕士,教授,硕士生导师,研究方向:中药药理与毒理学。 E-mail: 878104134@qq.com
  • 作者简介:李爽,女,在读硕士,从事中西医结合防治化疗损伤的相关研究。 E-mail: lishuang20220916@163.com
  • 基金资助:
    国家自然科学基金项目(82004228);甘肃中医药大学研究生创新基金项目(2022CX33)

Progress in the prevention and treatment of traditional Chinese medicine based on the mechanism of intestinal injury of various chemotherapy

LI Shuang 1,2, HAN Shuzhen3,4, DAI Yuting 5, XIU Minghui 1,3,5, DU Xianqin 1,2, HE Jianzheng1,3,4, LIN Xingyao 1,2   

  1. 1Provincial-level Key Laboratory for Molecular Medicine of Major Diseases and the Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and Universities, Lanzhou 730000, Gansu, China; 2Gansu Research Center of Traditional Chinese Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu, China; 3Key Laboratory of Molecular Medicine and Traditional Chinese Medicine Prevention and Treatment of Major Diseases in Gansu Universities, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu, China; 4School of Basic Medicine, Gansu Zhongshan University of Medicine, Lanzhou 730000, Gansu, China; 5School of Public Health, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu, China
  • Received:2022-11-21 Revised:2023-04-18 Online:2023-05-26 Published:2023-06-08

摘要:

肠损伤是临床应用化疗药物的常见不良反应,限制了化疗药的进一步应用,并给病人造成严重的身心负担。目前化疗肠损伤的发生机制比较复杂,中医药具有极好的防治作用。本文综述化疗引起肠道菌群失调、氧化应激、炎症反应、细胞凋亡、免疫损伤等造成肠损伤的相关机制,总结中医药防治的作用,将为防治化疗肠损伤的中药研发提供理论基础。

关键词: 化疗, 肠损伤, 机制, 中药, 防治

Abstract:

Intestinal injury is a common adverse reaction of clinical chemotherapy drugs, which limits the further application of chemotherapy drugs and causes serious physical and mental burden to patients. At present, the mechanism of chemotherapy-induced intestinal injury is complex, and traditional Chinese medicine has an excellent preventive effect. This article reviews the related mechanisms of intestinal flora imbalance, oxidative stress, inflammatory response, cell apoptosis, and immune damage caused by chemotherapy, and summarizes the role of traditional Chinese medicine in prevention and treatment of oxidative stress, inflammatory response, cell apoptosis , and immune damage.

Key words: chemotherapy, intestinal injury, mechanism, traditional Chinese medicine, prevention and treatment

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