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中国临床药理学与治疗学 ›› 2021, Vol. 26 ›› Issue (12): 1444-1448.doi: 10.12092/j.issn.1009-2501.2021.12.016

• 综述与讲座 • 上一篇    下一篇

瑞马唑仑的临床应用与研究进展

金宝伟1,蒋宗明1,郭建荣2   

  1. 1绍兴市人民医院麻醉科,绍兴 312000,浙江;2海军军医大学附属公利医院麻醉科,上海 200135
  • 收稿日期:2021-10-18 修回日期:2021-12-12 出版日期:2021-12-26 发布日期:2022-01-07
  • 通讯作者: 郭建荣,通信作者,男,博士,主任医师、教授,博士生导师,研究方向:麻醉基础与临床。 Tel: 18916174776 E-mail: jianrguo@126.com
  • 作者简介:金宝伟,男,硕士,主治医师,研究方向:麻醉基础与临床。 Tel: 15957577972 E-mail: baoweijin1981@163.com
  • 基金资助:
    浙江省自然科学基金项目(LY19H090006)

Clinical application and research progress of remimazolam

JIN Baowei1, JIANG Zongming1, GUO Jianrong2   

  1. 1Department of Anesthesiology, Shaoxing People's Hospital, Shaoxing 312000, Zhejiang, China; 2Department of Anesthesiology, Gongli Hospital, Naval Military Medical University, Shanghai 200135, China
  • Received:2021-10-18 Revised:2021-12-12 Online:2021-12-26 Published:2022-01-07

摘要: 瑞马唑仑是一种新型超短效镇静药物,具有起效和恢复快,代谢不依赖肝肾功能,呼吸抑制轻,血流动力学稳定,长时间应用无蓄积,羧酸代谢物无药理作用,能被拮抗药氟马西尼快速逆转,有望成为临床镇静药物的新选择。本文就瑞马唑仑的药理学特性和近期的研究进展作一综述,为临床的安全用药提供参考。

关键词: 瑞马唑仑, 镇静, 全身麻醉

Abstract: Remimazolam is a new ultra-short-acting sedative, with rapid onset and recovery, metabolism independent of liver and kidney function, light respiratory inhibition, stable hemodynamics, long time application without accumulation. Carboxylic acid metabolites have no pharmacological effects, and can be rapidly reversed by antagonist flumazenil, which is expected to become a new choice of clinical sedative. In this paper, pharmacological characteristics and recent research progress of remimazolam are reviewed, which can provide reference for clinical safe drug use.

Key words: remimazolam, calm, general anesthesia

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