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中国临床药理学与治疗学 ›› 2023, Vol. 28 ›› Issue (8): 910-917.doi: 10.12092/j.issn.1009-2501.2023.08.007

• 乳腺癌药物治疗新进展 • 上一篇    下一篇

肉芽肿性小叶性乳腺炎诊疗进展

王朝义,宋 强,熊 鑫,王梦远   

  1. 重庆大学附属三峡医院乳腺甲状腺外科,重庆  404100
  • 收稿日期:2022-09-26 修回日期:2023-04-03 出版日期:2023-08-26 发布日期:2023-08-29
  • 通讯作者: 王梦远,男,硕士,副主任医师,硕士生导师,主要从事乳腺良恶性疾病的诊治研究。 E-mail:wangchaoyi11223@outlook.com
  • 作者简介:王朝义,男,硕士,主治医师,主要从事乳腺良恶性疾病的诊治研究。 E-mail:18875211558@126.com
  • 基金资助:
    国家卫生计生委医药卫生科技发展研究中心项目(W2017QRX12);重庆市自然科学基金面上项目(cstc2020jcyj-msxmX0049);重庆市万州区科技计划项目(wzstc-2020017)

Research progress on diagnosis and treatment of granulomatous lobular mastitis

WANG Chaoyi, SONG Qiang, XIONG Xin, WANG Mengyuan   

  1. Department of Breast Surgery, Chongqing University Three Gorges Hospital, Chongqing 404100, China
  • Received:2022-09-26 Revised:2023-04-03 Online:2023-08-26 Published:2023-08-29

摘要:

肉芽肿性小叶性乳腺炎(granulomatous lobular mastitis,GLM)是一种罕见的乳腺慢性炎症性疾病,有时难以与乳腺癌鉴别。GLM病因尚不明确,目前研究表明其可能与自身免疫、激素水平异常和感染等有关。GLM缺乏特异性的临床表现,其诊断主要通过组织病理学活检明确。GLM的治疗包括随访观察、类固醇激素、免疫抑制剂、抗生素及手术等。目前GLM的临床诊疗仍有许多困惑,尚缺乏统一的诊疗共识。因此我们通过查阅国内外有关GLM的文献资料作一综述,旨在为其临床诊疗提供更多依据。

关键词: 肉芽肿性小叶性乳腺炎, 发病机制, 临床表现, 诊治

Abstract:

Granulomatous lobular mastitis (GLM) is a rare form of chronic inflammatory breast disease which may be sometimes difficult to distinguish from breast cancer. The cause of GLM is unknown, but may be associated with autoimmunity, abnormal hormone levels and infection. While GLM has no specific clinical manifestations, the diagnosis is principally established by histopathology. Therapeutic options for GLM range from observation to various medical treatments, such as steroids, immunosuppressants, and antibiotics, to surgical intervention. However, there are still many difficulties in the clinical diagnosis and treatment of GLM, and there is still no unified diagnosis and treatment consensus. So, we accomplished the present review through reviewing GLM-related domestic and foreign literature, aiming to provide the basis for rational clinical diagnosis and treatment. 

Key words: granulomatous lobular mastitis, pathogenesis, clinical manifestation, diagnosis and treatment

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