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中国临床药理学与治疗学 ›› 2024, Vol. 29 ›› Issue (2): 236-240.doi: 10.12092/j.issn.1009-2501.2024.02.014

• 综述与讲座 • 上一篇    

ω-3 PUFA在心力衰竭中的研究进展

余吉玲1,2,张  晶1,邓毅凡1,2,何胜虎1   

  1. 1扬州大学临床医学院 江苏省苏北人民医院心血管内科,扬州  225001,江苏;
    2扬州大学医学院,扬州  225001,江苏

  • 收稿日期:2023-09-28 修回日期:2023-12-06 出版日期:2024-02-26 发布日期:2024-02-02
  • 通讯作者: 张晶,男,博士,副主任医师,研究生导师,研究方向:冠心病及心力衰竭的基础与临床。 E-mail:zhangjingyjs@163.com
  • 作者简介:余吉玲,女,硕士研究生在读,研究方向:冠心病及心力衰竭的基础与临床。 E-mail: 2369913058@qq.com
  • 基金资助:
    江苏省中医药科技发展计划项目(MS2021077)

Advances in the study of ω-3 PUFA in heart failure

YU Jiling 1,2, ZHANG Jing1, DENG Yifan1,2, HE Shenghu1   

  1. 1Clinical Medical College, Yangzhou University, Department of Cardiovascular Medicine, Northern Jiangsu People's Hospital of Jiangsu Province, Yangzhou 225001, Jiangsu, China; 2Medical College of Yangzhou University, Yangzhou 225001, Jiangsu, China
  • Received:2023-09-28 Revised:2023-12-06 Online:2024-02-26 Published:2024-02-02

摘要:

游离脂肪酸作为心脏重要的能量代谢底物,在各种心血管疾病中发挥着重要的作用,ω-3多不饱和脂肪酸(omega-3 polyunsaturated fatty acid,ω-3 PUFA)是游离脂肪酸的一个重要分支,越来越多的研究证实其与心血管疾病密切相关。心力衰竭为常见的心血管问题,严重影响着人们的生活质量,研究显示,ω-3 PUFA在心力衰竭的发生发展中起着重要作用。本文拟对ω-3 PUFA在心力衰竭中的代谢、作用机制及治疗中的意义进行综述。

关键词: 心力衰竭, ω-3多不饱和脂肪酸, 研究进展

Abstract:

Free fatty acids, as important energy metabolism substrates for the heart, play an important role in various cardiovascular diseases; ω-3 PUFA, as an important branch of free fatty acids, has been confirmed by more and more researches to be closely related to cardiovascular diseases. Heart failure, as a common cardiovascular problem, seriously affects people's quality of life. Studies have shown that ω-3 PUFA plays a significant role in the development of heart failure. In this paper, we try to review the metabolism, pathogenesis and therapeutic significance of ω-3 PUFA in heart failure.

Key words: heart failure, omega-3 polyunsaturated fatty acid, advances of study

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