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中国临床药理学与治疗学 ›› 2024, Vol. 29 ›› Issue (7): 826-830.doi: 10.12092/j.issn.1009-2501.2024.07.013

• 综述与讲座 • 上一篇    下一篇

椎管内应用艾司氯胺酮的临床研究进展

孙玉峰1,杨小林1,丁  颖1,吕艳蓉1,吴宏伟1,杨  春2   

  1. 1南通大学附属如皋医院(如皋市人民医院)麻醉科,如皋  226500,江苏;2南京医科大学第一附属医院麻醉与围术期医学科,南京  210020,江苏

  • 收稿日期:2023-10-22 修回日期:2023-12-15 出版日期:2024-07-26 发布日期:2024-06-24
  • 通讯作者: 吴宏伟,男,硕士研究生,副主任医师,研究方向:麻醉与镇痛。 E-mail: 240573486@qq.com 杨春,男,主任医师,教授,博士生导师,研究方向:麻醉与脑科学。 E-mail: chunyang@njmu.edu.cn
  • 作者简介:孙玉峰,男,硕士研究生,副主任医师,研究方向:麻醉与镇痛。 E-mail: 12614957@qq.com
  • 基金资助:
    国家自然科学基金(81974171;82271254);江苏省双创团队领军人才项目(JSSCTD202144);南通市卫生健康委员会科研课题(MSZ2023075)

Clinical research progress of esketamine application within the spinal canal

SUN Yufeng1, YANG Xiaolin1, DING Ying1, LV Yanrong1, WU Hongwei1, YANG Chun2   

  1. 1 Department of Anesthesiology, Rugao Hospital affiliated to Nantong University (Rugao People's Hospital), Rugao 226500, Jiangsu, China; 2 Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210020, Jiangsu, China
  • Received:2023-10-22 Revised:2023-12-15 Online:2024-07-26 Published:2024-06-24

摘要:

艾司氯胺酮在国内上市不久,是一种静脉全麻药,在临床上广泛应用于各种全身麻醉和抗抑郁治疗。研究发现艾司氯胺酮可安全用于椎管内,在亚麻醉剂量下即可以产生镇痛、镇静和抗抑郁作用。本文综述了艾司氯胺酮在椎管内作用的机制、安全性、不良反应和各种临床应用,为进一步深入研究提供相应的参考。

关键词: 艾司氯胺酮, 椎管内, 镇痛, 抗抑郁

Abstract:

Esketamine, which was recently introduced in China, is a type of intravenous general anesthetic that is widely used in clinical practice for general anesthesia and anti-depression therapy. Studies have found that esketamine can be safely used to intrathecally produce analgesic, sedative, and anti-depressive effects at subanesthetic doses. This review summarizes the mechanism of action, safety, adverse reactions, and various clinical applications of esketamine intrathecally, so as to provide relevant references for further research.

Key words: esketamine, spinal canal, analgesia, antidepressant

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