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中国临床药理学与治疗学 ›› 2025, Vol. 30 ›› Issue (10): 1408-1416.doi: 10.12092/j.issn.1009-2501.2025.10.013

• 综述与讲座 • 上一篇    下一篇

中药天然产物预防血管再狭窄的作用及机制研究进展

罗加伟1，陈天旺1，王鑫宇1，刘娟2，黄波1，李利生1，徐尚福1，2   

  1. 1遵义医科大学基础药理教育部重点实验室暨特色民族药教育部国际合作联合实验室，遵义  563000，贵州；2遵义医科大学附属医院贵州省细胞工程重点实验室，遵义  563000，贵州

  • 收稿日期:2025-02-19 修回日期:2025-04-11 出版日期:2025-10-26 发布日期:2025-10-15
  • 通讯作者: 徐尚福，男，博士，教授，硕士生导师，研究方向：干细胞防治血管再狭窄。 E-mail： 74663965@qq.com
  • 作者简介:罗加伟，男，硕士，研究方向：中药防治血管再狭窄。 E-mail： 864899556@qq.com
  • 基金资助:
    国家自然科学基金（82060817，82460879）

Research progress on the effect and mechanism of natural products of traditional Chinese medicine in preventing vascular restenosis

LUO Jiawei1, CHEN Tianwang1, WANG Xinyu1, LIU Juan2, HUANG Bo1, LI Lisheng1, XU Shangfu1,2   

  1. 1Key Laboratory of Basic Pharmacology of Ministry of Education and Joint Laboratory of International Cooperation on Characteristic Ethnic Medicine of Ministry of Education, Zunyi Medical University, Zunyi 563000, Guizhou, China; 2Guizhou Provincial Key Laboratory of Cell Engineering, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, China
  • Received:2025-02-19 Revised:2025-04-11 Online:2025-10-26 Published:2025-10-15

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摘要：

经皮冠状动脉介入治疗（percutaneous coronary intervention，PCI）已广泛应用于冠状动脉粥样硬化性心脏病的临床治疗，并取得良好疗效，但术后血管重塑所致的血管再狭窄仍需关注，严重影响了PCI远期疗效，预防血管再狭窄对心血管疾病具有重要意义。中药天然产物因其具有多靶点、毒性低、安全性高的特点。近年来，越来越多的研究发现中药天然产物具有防治血管再狭窄的作用，并能够有效地控制其发生和发展。本文综述了黄酮类、生物碱类、萜及苷类、多糖及多酚类化合物等中药天然产物预防血管再狭窄的作用和机制，并分析总结了各类天然产物的作用和机制差异，为研发安全有效的预防血管再狭窄药物提供新思路。

关键词: 中药天然产物, 血管再狭窄, 血管平滑肌细胞, 作用机制, 研究进展 ,  

Abstract:

Percutaneous coronary intervention (PCI) has been widely applied in the clinical treatment of coronary atherosclerotic heart disease and achieved good therapeutic effects. However, vascular restenosis caused by postoperative vascular remodeling still needs attention, which seriously affects the long-term efficacy of PCI. The prevention of vascular restenosis is of great significance for cardiovascular diseases. Traditional Chinese medicine natural products, with their characteristics of multiple targets, low toxicity and high safety, have attracted increasing attention in recent years. More and more studies have found that traditional Chinese medicine natural products have the effect of preventing and treating vascular restenosis and can effectively control its occurrence and development. This article reviews the effects and mechanisms of flavonoids, alkaloids, terpenoids and glycosides, polysaccharides and polyphenols and other traditional Chinese medicine natural products in preventing vascular restenosis, and analyzes and summarizes the differences in the effects and mechanisms of various natural products, providing new ideas for the development of safe and effective drugs to prevent vascular restenosis.

Key words: natural products of traditional Chinese medicine, vascular restenosis, vascular smooth muscle cell, mechanism of action, research progress ,   

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