慢性肾小球疾病高血压及其对肾功能影响

中国临床药理学与治疗学 ›› 1996, Vol. 1 ›› Issue (2): 102-106.

慢性肾小球疾病高血压及其对肾功能影响

张道友, 叶任高¹, 卢智¹, 杨卫明¹

皖南医学院弋矶山医院,芜湖241001,¹中山医科大学

收稿日期:1996-09-18 修回日期:1996-10-18 发布日期:2020-12-03
作者简介:张道友,男,副教授,副主任医师,安微省肾脏病学会副主任委员,安徽省高校及卫生厅跨世纪学科带头人培养对象。叶任高,男,救授,主任医师.博士呀究生导师,中华医学会肾脏病学会常务委员,中华医学会肾脏病学会中西医结合学会主任委员。

Arterial Hypertension and its Influence on Renal Function in Chronic Glomerulonephritis

Zhang Daoyou¹, Ye Rengao¹, Lu Zhi¹, Yang W eiming¹

Wunnan Medical College, Wuhu 241001

Received:1996-09-18 Revised:1996-10-18 Published:2020-12-03
About author:I Renal Research Insitute, Sun Yat-Sen University of Merd ical Sciences, GuangZhou, Guangdong, 510080

摘要/Abstract

摘要： 目的了解慢性肾小球疾病时高血压发病情况及其对肾功能的影响。方法 520例住院病例,按WHO及中华医学会制订的形态学分类标准分组观察。结果高血压总发病率为32.7%,膜增生性肾炎、新月体肾炎及硬化性肾炎常发生高血压,而lgA肾病及徽小病变肾病较少发生高血压。在疾病早期,肾功能正常或轻微异常时常已发生高血压,经降压治疗后肾功能可改善。结论不同病理类型慢性肾小球疾:病高血压发病率不同,降压治疗可改善肾功能并延缓肾功能恶化速率。

关键词: 慢性肾炎, 高血压, 肾功能

Abstract: Aim To derermine the frequency of arerial byertension in chronic glomerulonepbri-tis. Methods Pive bundred and lwenty patens of chronic glomerlonephritis asifed mophogically acording to the criterin of the WHO's and Chinese Medical Asociaion were alyed rperiveley. Results The overal prevalerce of arerial hyertensin was 32.7% Hyerension was mot frequent in mrbraorplieretive exrpilaryy and scde trotic glomerulonephritis (P<0.05), but infrequent in IgA nephropathy and minimal lesion(P <0. 01): Hyperension often dveloped durng the early stage of the disease when renal fuction was nomal or minimal abhormal. Real function was ofen improved after antity. pertension therapy. Conclusion The frequency of the hypertension in dfferent subgroup was dferent. and nihyerension therapy might improre renal function and slow down the rate of progressive renal failure.

Key words: Chronic glomerulonephritis, Hypertension, Renal function

中图分类号:

R692

张道友, 叶任高, 卢智, 杨卫明. 慢性肾小球疾病高血压及其对肾功能影响[J]. 中国临床药理学与治疗学, 1996, 1(2): 102-106.

Zhang Daoyou, Ye Rengao1, Lu Zhi, Yang Weiming. Arterial Hypertension and its Influence on Renal Function in Chronic Glomerulonephritis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1996, 1(2): 102-106.

参考文献

1 Sinclair AM, Isles CG, Brown I, et al. Secondary hy pertension in a blood pressure clinic. Arch Intern Med 1987, 147: 1289
2 Orofino L, Quereda C,Lamos S, et al. Hyperten-sion in primary chronic glomerulonephritis: Analysis of 288 biopsied patients. Nephron, 1987, 45:22
3 Bell PE, Hossack KF,Gabow PA,et al. Hyper-tension in autosomal dominant polycystic kidney dis-ease. Kidney Int, 1988, 34: 683
4 Wang Haiyan, Zhen Falei, Liu Yuchun,et al. The conference about criteria of classify, diagnosis, and treuiment in primary glomerular disease. Chung Hua Nei Ko Tsa Chih, 1993, 32:131
5 Rustand SG, Brown G, Kirk KA, et al. Renal in-sufficiency in essential hypertension. N Engl J Med 1989, 320; 684
6 Aubia J, Hujman L,Chine M, et al. Hypertension and nephrotoxity in the rate of decline in kidney function in diabetic nephropathy. Clin Nephrol, 1987.27:15
7 Parving HH, Andersen AR, Smidt UM, et al. Effect of anti ihypertensive treatment on kidney function in diabetic nephropathy. Br Med J 1987, 294: 1443
8 Klahr S, Schreiner G, Ichikawa I. The progression of renal disease. N Engl J Med,1988, 318:1657
9 Brazy PC, Stead wW, Fitzwilliam JF. Progression of renal insufficiency: role of blood pressure. Kidney Int 1989, 35:670
10 Subias R, Botey A, Darnell A,et al. Malignant or accelerated hy pertension in IgA nephropathy. Clin Nephrol,1987, 27:1
11 Bergstrom J, Alvestrand A,Bucht H, et al. Progression of chronic renal failure in ma an is retarted with more frequent clinic followups and better blood pressure control. Clin Nephrol, 1989,25:1
12 Jacobson HR. Chronic renal failure: Pathophysiology. Lancet, 1991, 338:419
13 Klahr S. Chronic renal failure: Management. Lancet,1991, 338:423
14 Klahr S. The modification of diet in renal disease study. N Engl J Med, 1989, 320: 864

[1]	汪飞, 杭永付, 王未. 重症患者肾功能亢进对替考拉宁血药浓度影响分析[J]. 中国临床药理学与治疗学, 2023, 28(9): 1043-1048.
[2]	李士旭, 李林运, 王新, 李轲, 卞华. 银杏叶提取物通过miR-145/FOXO1轴对实验性肾功能衰竭大鼠肾脏损伤的影响[J]. 中国临床药理学与治疗学, 2023, 28(7): 728-735.
[3]	党子龙, 刘海洋, 张扬帆, 刘金凤, 张天为, 李斌, 郭鸿, 成文媛, 许晓辉, 李一乐, 魏玉辉, 武新安. 肾功能亢进ICU患者的抗菌药物给药方案调整策略研究进展[J]. 中国临床药理学与治疗学, 2023, 28(5): 561-571.
[4]	宁思思, 赵玉红, 颜蕾, 唐敏娜, 张凝之, 张泳巧, 崔兆强. 高血压合并慢性肾脏病患者的降压目标之争议[J]. 中国临床药理学与治疗学, 2023, 28(4): 463-467.
[5]	吴莉莉, 梁至, 黄思咏, 王妍. 肾功能亢进对感染性心内膜炎患者万古霉素药动学的影响及有效性与安全性研究[J]. 中国临床药理学与治疗学, 2023, 28(10): 1139-1145.
[6]	徐涛, 朱素燕, 邱相君, 徐萍. 肾功能不全患者人群中替考拉宁群体药代动力学模型的建立与验证[J]. 中国临床药理学与治疗学, 2022, 27(9): 977-983.
[7]	付虹, 田磊. 缺血性脑卒中伴高血压病患者个体化精准治疗的研究[J]. 中国临床药理学与治疗学, 2022, 27(8): 870-876.
[8]	陈文刚, 殷勤, 张巍巍, 周露露, 寇婉青, 袁小龙. 皖南地区高血压患者MTHFR基因多态性分布及与血Hcy相关性研究[J]. 中国临床药理学与治疗学, 2022, 27(7): 768-774.
[9]	林雪燕, 林志辉, 黄胡萍. 特利加压素对基线肾功能正常的肝硬化食管胃静脉曲张出血患者肾功能的影响[J]. 中国临床药理学与治疗学, 2022, 27(7): 775-784.
[10]	杜文鹏, 敖检根, 陶祎, 吴观胜, 何佳珂. 自身免疫疾病患者他克莫司稳态血药浓度影响因素的研究[J]. 中国临床药理学与治疗学, 2022, 27(6): 645-651.
[11]	张凝之, 赵玉红, 唐敏娜, 张泳巧, 宁思思, 崔兆强. 时辰药理学在高血压治疗中的应用[J]. 中国临床药理学与治疗学, 2022, 27(4): 418-422.
[12]	崔素梅, 崔兆强. β受体阻滞剂与高血压治疗[J]. 中国临床药理学与治疗学, 2022, 27(4): 423-427.
[13]	李远方, 崔兆强. 高血压合并高尿酸血症的应对之策[J]. 中国临床药理学与治疗学, 2022, 27(4): 428-432.
[14]	徐建飞, 林利. 高血压药物治疗与非药物治疗研究进展[J]. 中国临床药理学与治疗学, 2022, 27(4): 433-441.
[15]	蒯铮, 张潇伊, 邹云增. 血管紧张素受体脑啡肽酶抑制剂在老年高血压中的应用[J]. 中国临床药理学与治疗学, 2022, 27(4): 442-445.