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中国临床药理学与治疗学 ›› 1997, Vol. 2 ›› Issue (2): 92-94.

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党参、白芨、制大黄及其配伍抗大鼠实验性胃溃疡作用

刘海鹏, 陈向涛1, 江惠丽2   

  1. 安徽省立医院分院, 合肥 230031;1安徽中医学院;2安徽中医学院附二院
  • 收稿日期:1997-04-07 修回日期:1997-04-23 发布日期:2020-12-06
  • 作者简介:刘海鹏, 男, 29岁, 住院医师, 医学学士, 专业方向:中医药消化系统 临床治疗及研究。陈向涛, 30岁, 主治医师, 医学碩士, 主要从事胃粘膜保护的中药研究。

Effects of codonopsis pilosula, bletilla striata prepared rheum palmatum and their formuia on Experimental ulcer models in rats

Liu Haipeng, Chen Xiangtao, Wang Huili   

  1. Anhui Provincial Hosptal, Hefei 230031
  • Received:1997-04-07 Revised:1997-04-23 Published:2020-12-06

摘要: 目的 观察党参、白芨、制大黄及其配伍对实验性大鼠胃溃疡的作用。方法 采用无水G醇致胃 粘膜损伤, 幽门结扎诱发胃溃疡和乙S交诱发慢性胃溃疡三种模型, 观察党参、白芨、制大黄及配伍 对溃疡、指数胃分泌、胃壁粘液量和胃粘膜血流量的影响。结果与结论 三药及其配伍均不同程 度地降低了三种模型的溃疡指数, 复方疗效好于党参;且三药及其复方不同程度地增加了胃壁粘 液分泌量和胃粘膜血流量。影响胃壁粘液分泌和胃粘膜血流量可能是其作用的原因之一。

关键词: 溃疡病, 大鼠, 药物联合作用, 党参, 白芨, 大黄

Abstract: Aim and Methods Effects of codonoposis pilosula, bletilla, striata prepared rheum palmaturn and their formula respectively on experimental ulcer model induced by ethanol, ulcer model induced by pylorus-ligation and chronic ulcer model induced by ethanoic acid in rats were observed, and the amount of gastric secretion, gastric mucus and mucosa blood flow was also determined to provide clues to evaluation of their effects. Result The results showed that the drugs and their formula respectively decreased the idexes of ulcer in different models to varying degree, and that they increased the amount of gastric mucus and gastric muscosa blood flow. Conclusion Drugs have better cruative effect for gastric ulcer, and the effect may partly result from their influences on the mucus secretion and gastric mucosa blood flow.

Key words: words ulcer, rat, drug combination action, codonopsis pilosula , bletilla striata , rheum palmatun

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