壮骨康齿胶囊对大鼠雌二醇含量及牙周组织的影响

中国临床药理学与治疗学 ›› 1998, Vol. 3 ›› Issue (1): 41-43.

壮骨康齿胶囊对大鼠雌二醇含量及牙周组织的影响

杨更森, 侯晓薇, 马志, 李俊敏

河北医科大学第三医院, 石家庄050051

收稿日期:1997-07-16 修回日期:1997-12-23 出版日期:1998-03-26 发布日期:2020-12-04
作者简介:杨更森, 男, 45 岁, 副教授。侯晓薇, 女, 32 岁, 讲师。
基金资助:
河北省中医局资助立项课题

Effect of Zhuanggukangchi capsule, a preparation of traditional chinese medicine, on estrogen level and periodontal tissue in rats

YANG Geng-Sen, HOU Xiao-Wei, MA Zhi, LI Zun-Min

Department of Stomatology, Hebei Medical University, Shijiazhuang 050051

Received:1997-07-16 Revised:1997-12-23 Online:1998-03-26 Published:2020-12-04

摘要/Abstract

摘要： 目的观察壮骨康齿胶囊对大鼠雌二醇含量及牙周组织发育的影响。方法选用40 只雌性大鼠随机分成两组, 每组20 只, 用药组每日灌胃壮骨康齿胶囊配制的药液1 ml(含药量30 mg), 对照组每日灌胃蒸馏水1 ml, 连续30 天后, 取血测定两组大鼠雌二醇含量, 解剖子宫卵巢称重, 计算子宫重量指数;选择32 只雌性大鼠分两组, 每组16 只, 喂药方法同前, 分别于第1、4、8、12 周处死大鼠,取下颌前牙的牙周组织作组织学切片, 光镜观察。结果实验用药组雌二醇含量、子宫卵巢重量, 子宫重量指数均明显高于对照组(P<0.01);用药组牙龈上皮、牙周膜明显增厚, 肌纤维明显增粗。结论壮骨康齿胶囊可以明显提高大鼠雌二醇含量, 促进牙周组织的发育。

关键词: 壮骨康齿胶囊, 雌二醇, 牙周组织, 大鼠

Abstract: Aim To investigate the effect of Zhanggukangchi capsule on estrogen level and the development of periodontal tissue in rats.Methods Forty female rats were divided into experimental and control groups in the former.Every rat was perfused with 1 ml Zhuang gukangchifluidper day in the latter, and rats were perfused with distilled water, and 30 days later, the est radial content was detected, and the weight of rat body and their utero-ovarian were measured;In addition, another 32 female rats were also divided into experimental and cont rol groups and fed as discribed aboue.Every 4 rats from each group were killed in 1, 4, 8 and 12 weeks respectively. The histolo gical characte ristics of periodontal tissue materials were observed with light microscope.Results The est radial content, weight of ute ro-o variam, and index of uters/a rium in experimental group were hig her significantly than those in the control group (P<0.01)and gingival epthelial hy perplasia, pericementum and periodontal fibre were thickened.Conclusion It is revealed that Zhuang gukangchicapsule may increase extrogen level distinctly and promote the development of periodontal tissue.

Key words: rat, estrogen, Zhuanggukangchi capsule, periodontal tissue

中图分类号:

R977.12

杨更森, 侯晓薇, 马志, 李俊敏. 壮骨康齿胶囊对大鼠雌二醇含量及牙周组织的影响[J]. 中国临床药理学与治疗学, 1998, 3(1): 41-43.

YANG Geng-Sen, HOU Xiao-Wei, MA Zhi, LI Zun-Min. Effect of Zhuanggukangchi capsule, a preparation of traditional chinese medicine, on estrogen level and periodontal tissue in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1998, 3(1): 41-43.

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