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中国临床药理学与治疗学 ›› 1999, Vol. 4 ›› Issue (1): 30-32.

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补肾延寿胶囊抗衰老作用

陈金和,汪晖, 丁虹, 黎七雄, 孔锐   

  1. 湖北医科大学药理教研室,武汉 430071
  • 收稿日期:1998-12-21 修回日期:1999-01-11 出版日期:1999-03-26 发布日期:2020-12-03
  • 作者简介:陈金和,男,54岁,教研室主任,教授,从事生化药理方面的工作和研究。

Antisenescent action of capsule bushenyanshou

CHEN Jin-He, WANG Hui, DING Hong, LI Qi-Xiong, KONG Rui   

  1. Deparlment of Phar macology, Hubei Medical University, WuHan 430071
  • Received:1998-12-21 Revised:1999-01-11 Online:1999-03-26 Published:2020-12-03

摘要: 目的 观察补肾延寿胶囊对实验动物抗氧化功能、耐寒及抗疲劳功能的影响。方法 检测补肾延寿胶囊对老龄大鼠血红细胞超氧化物歧化酶(SOD)、组织丙二醛(MDA)含量以及阳虚症小鼠体重、体温和冰水游泳时间的影响。结果 补肾延寿胶囊(0.4、0.8g/kg ig,叫qd ×21日)既能升高老龄SD大鼠血红细胞SOD比活性,明显降低肝和脑组织MDA含量,也能增加氬化泼尼松所致阳虚症小鼠的体重、体温和冰水游泳时间。结论 结合补肾延寿股囊对免疫功能的增强和调节作用,提示补肾延寿胶囊具有一定的抗衰老作用。

关键词: 补肾延寿胶囊, 抗衰老, 超氧化物歧化酶, 丙二醛, 阳虚症

Abstract: Aim The effect of capsule bushenyanshou (BSYS) on the antioxidative function, and the tolerance of cold and fatigue in rats was investigated. Methods The activity of erythro-cytic superoxide dismutase (SOD), the contents of brain and liver malondialdehyde (MDA) in rats and the changes of body weight, body temperature and the swimming time at (TC in mice were measured. Results Capsule BSYS(400, 800 mg/kg, ig, qd × 21d) increased erythrocytic SOD activity and markedly reduced brain and liver homogenate MDA contents in ole rat and enhanced ihe body weight and body temperature, and prolonged the swim-ming time at 0℃ in hydrocortisone-treated(15 mg/kg, sc, qd × 5 d) mice. Conclusion Capsule BSYS has a certain antisenescent action.

Key words: capsule bushenyanshou, antisenescent action, erythrocytic superoxide dis-murase, malondialdehyde, hydrocortisone-treated mice

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