复方雷公藤多甙对雌性大鼠生殖系统的影响

中国临床药理学与治疗学 ›› 1999, Vol. 4 ›› Issue (4): 319-321.

复方雷公藤多甙对雌性大鼠生殖系统的影响

梁文波, 董何彦¹, 冷萍²

大连大学基础医学部药理教研室,大连 116622;¹大连大学生物医学研究所;²大连大学成人教育学院

收稿日期:1999-03-25 修回日期:1999-05-28 发布日期:2020-11-27
作者简介:梁文波,男,35岁,医学硕士。

Effect of multiglycosides of tripyergium wilfordii (GTW) compound on female rat reproductive system

LINAG Wen-Bo, DONG He-Yan¹, LENG Ping²

Department of Pharmacology, ¹Biomedical Research Institute;²Adult Educational collge, Dalian Medical University, Dalian 116622

Received:1999-03-25 Revised:1999-05-28 Published:2020-11-27

摘要/Abstract

摘要： 目的探讨复方雷公藤多甙对雌性大鼠生殖系统的影响。方法以瓜蒌、石斛、白勺、川芎、生地、当归、五味子、菟丝子、枸杞子、车前子、复盆子、益母草、泽兰组成的中药复方,其水提剂11.27, 5.64,2.82 g·kg^-1与雷公藤多甙组成复方雷公藤多甙给大鼠ig。结果三个剂量的复方雷公藤多甙均能不同程度地纠正雷公藤多式导致的大鼠动情周期异常、子宫重量减轻及子宫肌层变薄,各实验纽卵巢未见明显变化。结论复方雷公藤多甙对雌性大鼠生殖系统的毒副作用明显低于雷公藤多甙。

关键词: 复方, 雷公藤多甙, 生殖系统

Abstract: Aim The side and toxic effects on reproductive system of female rat caused by compositus GTW were observed. Methods In three dosages (11.27 g·kg^-1, 5.64.g·kg^-1and2.82g·kg^-1of each ary herbs), the 13 specified traditional Chinese medical herbs, including Trichosanthes Kirilowii, dendronium clavatum, Paeonia lactiflora,et al. were detected and concentrated to 10 ml·kg^-1 decoctums. The decoctums were each mixed with 30 g·kg^-1 GTW to compose the GTW compounds. GTW and GTW compounds, in the same dose, were given separetely to the rats in different groups for 80 days. Cytological examination was performed 10 days before finishing the experiment and changes of uterus and ovary were observed after the experiment.Results In the GTW group the ovulatory period was irregular, the weight of uterus was lost and its muscle became thinner, as compared with those in the control group, while in the GTW compound groups the toxic effects found in the GTW group were apparently redressed.Conclusion The side and toxic effects of GTW compound on reproductive system of female rats are apparently lower than those of GTW.

Key words: multiglycoside of tripyergium wilfordii, compound reproductive system

中图分类号:

R965

梁文波, 董何彦, 冷萍. 复方雷公藤多甙对雌性大鼠生殖系统的影响[J]. 中国临床药理学与治疗学, 1999, 4(4): 319-321.

LINAG Wen-Bo, DONG He-Yan, LENG Ping. Effect of multiglycosides of tripyergium wilfordii (GTW) compound on female rat reproductive system[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1999, 4(4): 319-321.

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