茶多酚对家犬的长期毒性作用

中国临床药理学与治疗学 ›› 2000, Vol. 5 ›› Issue (1): 43-46.

茶多酚对家犬的长期毒性作用

赵亚男, 柯永胜, 郑青山, 桂常青¹

皖南医学院弋矶山医院;
¹药理教研室,芜湖 241001

收稿日期:2000-01-03 出版日期:2000-03-26 发布日期:2020-11-26
作者简介:赵亚男,女,主管药师。

Chronic toxicity of tea polyphenols in dogs

ZHAO Ya-Nan, KE Yong-Sheng, ZHENG Qing-Shan, GUI Chang-Qing¹

Yijishan Hospital;
¹Department of Pharmacology,Wannan Medical College,Wuhu 241001

Received:2000-01-03 Online:2000-03-26 Published:2020-11-26

摘要/Abstract

摘要： 目的观察用药 90 d 及停药 2 kw 后,茶多酚(TP)对家犬的长期毒性反应。方法家犬以 650、65、6.5 mg·kg^-1·d^-13个剂量分别连续饲服 TP90 d 及停药 2 kw 后,观察动物的一般情况、检查动物的心电图、血尿常规、血脂、血糖、凝血时间、肝肾功能等生化指标。结果用药组体重增加情况与对照组无显著性差异(P>0.05);用药前、服药中、停药后家犬的活动情况、毛发、粪便、心电图、血尿常规、各项生化指标均未见异常,用药前后比较无显著性差异(P>0.05);大、中、小剂量组血清胆固醇水平进行性降低。结论 TP按 650 mg·kg^-1·d^-1饲服 90 d 对家犬未见明显毒性作用。

关键词: 茶多酚, 长期毒性, 家犬

Abstract: Aim The chronic toxicity of tea polyphenols(TP)in dogs was observed.Methods 18 dogs were randomly divided into high,middle and low dose TP groups and one control group.When TP was given(po)by 650mg·kg^-1·d^-1,65mg·kg^-1·d^-1,6.5mg·kg^-1·d^-1re-spectively for 90 d and after TP was stopped for two weeks,the general conditions,ECG,blood routine,urine routine,serum lipids,blood sugar,coagulation time,and hepatic and kidney function were detected respectively.Results These mdices were not different from each other among the 4 groups before,during and after administration of TP.The level of serum total cholesterol was progressively decreased in TP groups.Conclusion TP has no toxic effect on dogs and can decrease the level of serum total cholesterol in normal dogs.

Key words: tea polyphenols, chronic poisoning, dogs

中图分类号:

R285.1

赵亚男, 柯永胜, 郑青山, 桂常青. 茶多酚对家犬的长期毒性作用[J]. 中国临床药理学与治疗学, 2000, 5(1): 43-46.

ZHAO Ya-Nan, KE Yong-Sheng, ZHENG Qing-Shan, GUI Chang-Qing. Chronic toxicity of tea polyphenols in dogs[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2000, 5(1): 43-46.

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