冠脉内注射腺苷减少急性心肌梗死直接PTCA 术中无再流的发生

摘要/Abstract

摘要： 目的探讨冠状动脉内注射腺苷对急性心肌梗死急诊直接PTCA 术中无再流现象发生的影响。方法 79 例急性心肌梗死患者被随机分配到腺苷组(51例) 和非腺苷组(28 例), 腺苷给药方法为在每次球囊扩张前及其后冠状动脉内弹丸式注射24～48 μg。结果非腺苷组有8 例出现无血流(28.6%), 腺苷组有3 例出现无血流(5.9%)。注射腺苷患者未见明显合并症。结论对于急性心肌梗死患者, 急诊PTCA 术中冠状动脉内注射腺苷安全有效, 无再流发生率显著降低, 因此对改善患者预后具有极为重要的意义。

关键词: 急性心肌梗死, 腺苷, 经皮冠状动脉腔内成形术, 无再流现象

Abstract: Aim To investig ate the role of intracoronary adenosine for the prevention of no reflow.Methods The procedural outcomes of 79 patient s who undertook percutaneous intervention in the setting of acute myocardial infarction was studied.Twenty-eight patients did not received int racoronary adenosine, and fiftyone received intracoronary adenosine bolluses (24-48 μg before and after each balloon inf lation).Results Eight patients who were not given adenosine experienced no reflow (28.6%) and high in-Hospital death rate, three of fif ty-one patients (5.9%) in the adenosine group experienced no reflow.No untoward complications were noted during adenosine infusion. Conclusion Int racoronary adenosine bolus administration during percutaneous intervention in the patients with acute my ocardial infarction is easy and safe and may significant lylessen the incidence of no reflow and may improve the outcome of this procedure.

Key words: acute myocardial infarction, adenosine, percutaneous transluminal coronary angioplasty, noreflow phenomenon

中图分类号:

陈绍良, 袁争白, 叶飞, 方五旺, 宋杰, 查铭凡, 陈怀沁, Tamari. 冠脉内注射腺苷减少急性心肌梗死直接PTCA 术中无再流的发生[J]. 中国临床药理学与治疗学, 2001, 6(4): 295-300.

CHEN Shao-Liang, YUAN Zen-Bai, YE Fei, FANG Wu-Wang, SONG Jie, TAN Huai-Qing, Tamari. Intracoronary adenosine decreases the incidence of no reflow during percutaneous intervention in patients with acute myocardial infarction[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2001, 6(4): 295-300.

参考文献

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