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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (5): 424-427.

• 研究原著 • 上一篇    下一篇

丹皮多糖-2b 降血糖作用的实验研究

刘丽萍, 洪浩1, 王钦茂1, 刘超1, 赵帜平2   

  1. 安徽医科大学第一附属医院药剂科, 合肥 230038;
    1安徽中医学院药理教研室, 合肥 230038;
    2安徽大学生命科学院, 合肥 230039
  • 收稿日期:2002-05-13 修回日期:2002-06-02 发布日期:2020-11-26
  • 通讯作者: 刘丽萍, 女, 主管药师, 主要从事临床药学工作。Tel:0551-3633411-2423
  • 作者简介:王钦茂, 男, 教授, 硕士生导师。主要从事中药新药的药理学研究。洪浩, 男, 博士生。

Experimental study of the hypoglycemic activity of cortex moutan polysaccharide-2b

LIU Li-Ping, HONG Hao1, WANG Qin-Mao1, LIU Chao1, ZHAO Zhi-Ping2   

  1. Department of Pharmaceutics, First Hospital Affiliated to Anhui Medical University, Hefei 230038;
    1Department of Pharmacology, Anhui College of TCM, Hefei 230038;
    2School of Life Science, Anhui University, Hefei 230039
  • Received:2002-05-13 Revised:2002-06-02 Published:2020-11-26

摘要: 目的 研究丹皮多糖-2b (CMP-2b)降血糖作用及作用机制。 方法 用小鼠和大鼠建立葡萄糖性高血糖及四氧嘧啶性糖尿病模型, 氢化可的松琥珀酸纳(HCSS)诱导胰岛素抵抗, 观察丹皮多糖-2b 对正常和高血糖模型动物的影响, 并测定糖尿病动物SOD、Insulin、GHb、ApoA1 等水平。 结果 CMP-2b 可降低葡萄糖和四氧嘧啶诱发的鼠高血糖, 并能升高糖尿病小鼠SOD 和大鼠ApoA1 水平, 降低GHb 水平, 改善小鼠胰岛素抵抗。 结论 CMP-2b 可有效地控制实验性高血糖, 其降糖机理可能与改善机体对胰岛素的敏感性, 促进外周组织对葡萄糖的利用有关。

关键词: 丹皮多糖-2b, 降血糖作用, 糖尿病模型, 胰岛素抵抗

Abstract: AIM: To study the hypoglycemic action of cortex moutan polysaccharide-2b (CMP-2b)and the its mechanism. METHODS: Some animal models in this study included the glucose-induced hyperglycemic model in mice, the alloxan-induced diabetic model in mice and rats, and the HCSS-induced insulin resistance model in mice.Those models were used to investigate the effects of CMP-2b on blood glucose of normal and hyperglycemic model animals, on serum superoxide dismutase (SOD), serum insulin, glycated hemoglobin (GHb), and apolipoproteinA1 (ApoA1) in alloxan diabetic animals. RESULTS: CMP-2b significantly lowered the blood glucose in hyperglycemic mice and rats induced by glucose and alloxan.CMP-2b also raised the SOD and ApoA1 level, decreased the GHb level in diabetic animals, and improved insulin resistance in mice. CONCLUSION: CMP-2b can control experimental hyperglycemia.Its mechanism is related to improving insulin sensitivity and enhancing the utilization of glucose in peripheral tissues.

Key words: cortex moutan polysaccharide-2b (CMP-2b), hypoglycemic activity, diabetic model, insulin resistance

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