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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (4): 374-380.

• 研究原著 • 上一篇    下一篇

调节内皮细胞功能的新化合物哌芳安他抗动脉粥样硬化作用1

王倩, 汪海   

  1. 军事医学科学院毒物药物研究所,北京 100850
  • 收稿日期:2003-03-31 修回日期:2003-04-14 出版日期:2003-08-26 发布日期:2020-11-19
  • 通讯作者: 汪海,男,博士,研究员,博士生导师,主要从事分子药理学和心脑血管创新药物的研究。Tel:010-6693-2651  Fax :010-68211656 E-mail:wh@nic.bmi.ac.cn.
  • 作者简介:王倩,女,硕士研究生,副主任药师,主要从事药理学和抗动脉粥样硬化药物的研究。
  • 基金资助:
    1 国家重点基础研究发展规划项目(GT1998051112);赛德维康医药研究院新药研究基金(No1999001)

Effects of vascular novel compoundPivanampeta on modulating function of endothelium against atherosclerosis1

WANG Qian, WANG Hai   

  1. Institute ofPharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China
  • Received:2003-03-31 Revised:2003-04-14 Online:2003-08-26 Published:2020-11-19

摘要: 目的 研究新化合物哌芳安他的抗动脉粥样硬化作用。方法 以主动脉大体斑块分级和光镜下动脉粥样硬化病变分级为指标,观察哌芳安他对高脂饮食诱导的兔和鹌鹑动脉粥样硬化形成的影响。结果 可刺激NO和PGI2从内皮细胞释放的新化合物哌芳安他,对高血脂兔和鹌鹑血脂水平无明显影响,而能延缓高血脂诱导的兔主动脉和冠状动脉,及鹌鹑主动脉和头臂动脉的动脉粥样硬化病变形成。结论 新化合物哌芳安他具有延缓高血脂诱发的动脉粥样硬化病变形成的作用。

关键词: 药理学, 动脉粥样硬化, 高胆固醇血症, 内皮细胞功能障碍, 模型, 氧化应激

Abstract: AIM: To investigate the effects of novel compoundPivanampeta against atherosclerosis.METHODS: The effects ofPivanampeta against atherogenesis were evaluated with rabbits and quails fed with cholesterol-rich diet.RESULTS: Pivanampeta,the novel compound could stimulate the release of nitric oxide,PGI2from endothelium,and had no effect on thelevels of serumlipids.Pivanampeta significantly decreased thelesions of aorta and coronary artery of rabbits,and aorta and brachiocephalic artery of quails.CONCLUSION: Pivanampeta has experimental therapeutic effects against atherosclerosis induced by hypercholesterolemia in rabbits and quails.

Key words: pharmacology, atherosclerosis, hypercholesterolemia, endothelial dysfunction, model, oxidative stress

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