关键词: 药效学, 缬沙坦, 盐敏感性, 高血压, 血管紧张素Ⅱ, 醛固酮

Abstract: AIM: To investigate the interference of valsartan on bloodPressure andPlasma angiotensinⅡ(angⅡ),aldosterone(ALD)in salt sensitive essential hypertensivePatients.METHODS: Eighty-four adult hypertensivePatients were enrolled in study,and the salt sensitivity was determined by acute intravenous salt waterloading according to Sullvan' s criteria.The change of bloodPressure andPlasma angⅡ,and ALD were compared before and after the treatment.RESULTS: At the end of 2,4,6,and 8 weeks,patients with salt sensitive essential hypertensive(grouPss)and no salt sensitive essential hypertensive(grouPnss)were measured.The results showed that sitting systolic bloodPressure(SiSBP)was decreased by 17.5±4.3 and 11.0±1.4 mmHg,and sitting diastolis bloodPressure(SiDSP)was decreased by 17.0±3.7 and 7.3±1.1 mmHg after the treatment.It was found thatPatients showed significantly higherPlasma angⅡ andlowerPlasma ALD in grouPss and grouPnss.CONCLUSION: Valsartan can significantly control SiSBPand SiDBPfor both groups,interferedPlasma angiotensinⅡ and I aldosterone,and be more effective forPatients with salt sensitive essential hypertensive.

Key words: pharmacodynamics, valsartan, salt sensitive, hypertensive, angiotensinⅡ, aldosterone