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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (4): 444-446.

• 研究原著 • 上一篇    下一篇

黄芪注射液对老年急性心肌梗死患者左心功能的影响

张金国, 高东升, 华忠萍, 杨娜1, 刘立新, 刘雪玲   

  1. 济宁医学院附属医院心内科,济宁 272029,山东;
    1河北省人民医院心脏中心,石家庄 050051,河北
  • 收稿日期:2002-11-14 修回日期:2002-04-09 出版日期:2003-08-26 发布日期:2020-11-19
  • 通讯作者: 张金国,男,硕士,副主任医师,主要从事心力衰竭基础及临床研究。Tel:0537-2256225  E-mail:jgzhang@ 183.ha.cn

Effects of Astragalus Injection onleft cardiac function in elderlyPatients with acute myocardial infarction

ZHANG Jin-Guo, GAO Dong-Sheng, HUA Zhong-Ping, YANG Na1, lIUli-Xin, lIU Xue-Ling   

  1. Department of Cardiology,Affiliated Hospital of J ining Medical College,Jining 272029,Shandong,China;
    1CardiologyCentre,People' s Hospital of Hubei,Shijiazhuang 050051,Hubei,China
  • Received:2002-11-14 Revised:2002-04-09 Online:2003-08-26 Published:2020-11-19

摘要: 目的 评价黄芪注射液对老年急性心肌梗死(AMI)患者左心功能的影响。方法 92 例老年AMI患者随机分为黄芪组(46 例)和常规组(46 例),于治疗4 wk 后,行核素心血池心室造影,测定左室射血分数(LVEF)、左室峰射血率(PER)、左室峰充盈率(PFR)及左室峰充盈率时间(TPFR),以判断左室收缩与舒张功能;同时,观察两组患者梗死后心绞痛发生率;并于梗死8 wk 后随访两组患者,评定NYHA心功能分级。结果 治疗4 wk 后,黄芪组LVEF 、PER及PFR 明显提高,TPFR 缩短(P<0.05);梗死后心绞痛发生率黄芪组稍低于常规组,两组无统计学意义(P>0.05)。8 wk 后随访,NYHA 心功能分级黄芪组低于常规组,两组比较差异显著(P=0.0025)。结论 黄芪注射液是改善老年AMI 患者心脏功能的有效药物之一。

关键词: 药效学, 心肌梗死, 左室功能, 黄芪

Abstract: AIM: To evaluate effects of Astragalus Injection onleft cardiac function in elderlyPatients with acute myocardial infarction(AMI).METHODS: 92elderlyPatients with AMI were randomly divided into Astragalus Injection treatment grouPand control group.The cardiac systolic and diastolic functions were assessed by nuclide gating cardiac blood-pool imaging in allPatients after 4 wk treatment.AllPatients were followed uPfor 8thweek after infarction.RESULTS: Compared with control group,left ventricular ejection fraction(lVEF),left ventricularPeak ejecting rate(PER)andleft ventricularPeak filling rate(PFR)were higher,andleft ventricular time forPeck filling rate(TPFR)was shorter in treatment group.The attack rate of anginaPectoris waslower slightly in treatment group,but not significantly than that in control group.NYHA classes werelower in treatment group,and the difference of NYHA class between two groups had significance(P=0.0025).CONCLUSION: Astragalus Injection is an effective drug in improvingleft cardiac function in elderlyPatients with AMI.

Key words: pharmacodynamics, myocardium infarction, left cardiac function, Astragalus injection

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