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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (6): 652-654.

• 研究原著 • 上一篇    下一篇

可乐定对气管拔管患者应激反应的影响

石碧明, 任永功, 张雪萍, 李亚骊   

  1. 暨南大学医学院附属深圳市人民医院,深圳 518020,广东
  • 收稿日期:2003-05-28 修回日期:2003-07-07 出版日期:2003-12-26 发布日期:2020-11-19
  • 通讯作者: 石碧明,男,硕士,副主任医师,研究方向:麻醉应激反应的防治。Tel:075525533018-2591  E-mail:sbming@msn.com

Effects of oralPremedication with clonidine on stress response during tracheal extubation

SHI Bi-Ming, REN Yong-Gong, ZHANG Xue-Ping, LI Ya-LI   

  1. Department of Anesthesiology,ShenzhenPeople' s Hospital,Jinan University,Shenzhen 518020,Guangdong,China
  • Received:2003-05-28 Revised:2003-07-07 Online:2003-12-26 Published:2020-11-19

摘要: 目的 探讨可乐定对气管拔管应激反应的预防作用。方法 22 例气管插管全麻手术病人,随机分为对照组和可乐定组(每组11 例)。可乐定组病人于麻醉前60 min 加服可乐定5μg·kg-1,其它麻醉前用药两组病人相同。分别在麻醉前、拔管前、拔管后1 、2 、5 、10 min 采集动脉血标本,测定血浆儿茶酚胺、血管紧张素Ⅱ 、皮质醇、血糖、血乳酸浓度,做血气分析,计录各时点的血流动力学参数。结果 两组病人气管拔管期间血浆儿茶酚胺、皮质醇、血糖、血乳酸浓度均明显增高,可乐定组增高程度明显低于对照组。结论 麻醉前服用可乐定能明显减轻气管拔管引起的应激反应。

关键词: 药效学, 气管拔管, 应激反应, 可乐定, 术前用药法

Abstract: AIM: To investigate the effect ofPremedication with clonidine on the concentrations of catecholamine(CA),angiotentionⅡ(AⅡ),cortisol and carbohydrate metabolism during tracheal extubation.METHODS: Twenty-twoPatients scheduled for general anesthesia with tracheal intubation were randomly divided into two groups:clonidine grouPand control group.OralPremedication with clonidine 5μg·kg-1was taken in clonidine grouP60 min before anesthesia induction in addition to some commonPremedication in both groups.The change of hemodynamics,arterialPlasma concentrations of CA,AⅡ,cortisol,blood sugar andlactic acid were measured before anesthesia,before intubation and 1,2,5,10 min after tracheal extubation,respectively.RESULTS: Thelevels of CA,AⅡ,cotisol,blood sugar andlactic acid were significantly increased during tracheal extubation in both groups,but thelevels in control grouPwere higher than those in clonidine group.The change of hemodynamics was more stable in clonidine grouPthan that in control group.CONCLUSION: OralPremedication with clonidine can alleviate stress response during tracheal extubation.

Key words: pharmacodynamics, tracheal extubation, stress, clonidine, premedication

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