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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (12): 1403-1407.

• 研究原著 • 上一篇    下一篇

荔枝核皂苷对高脂血症-脂肪肝大鼠的降血糖调血脂作用

郭洁文, 廖惠芳1, 潘竞锵2, 叶碧波3, 简小兵4, 魏丹蕾4, 戴莲仪4   

  1. 广州市中医医院药剂科, 4内分泌科, 广州 510130, 广东;
    1广州中医药大学药理研究室, 广州 510405, 广东;
    2广州市中医中药研究所药理研究室, 广州 510130, 广东;
    3广东省药物研究所植化室, 广州 510180, 广东
  • 收稿日期:2004-09-29 修回日期:2004-11-16 出版日期:2004-12-26 发布日期:2020-11-19
  • 通讯作者: 潘竞锵, 男, 主任药师, 从事抗糖尿病和胰岛素增敏剂的药理研究。Tel:020-81953030 E-mail:zysgz@163.com
  • 作者简介:郭洁文, 女, 副主任药师, 从事药剂学、临床药学以及抗炎和抗糖尿病药物的研究和开发工作。Tel:020-81962900 E-mail:guo774@sina.com
  • 基金资助:
    广东省中医药局滚动资助项目(No302002);广州市医药卫生科技项目(No2004107)

Effects of saponin of Litchi on decreasing blood glucose and controlling blood lipid in hyperlipemia-fatty liver rats fed by ligh-sugar-fat

GUO Jie-Wen, LIAO Hui-Fang1, PAN Jing-Qiang2, YE Bi-Bo3, JIAN Xiao-Bing4, WEI Dan-Lei4, DAI Lian-Yi4   

  1. Department of Agent, 4Departemnt of Endocrine, Guangzhou Hospital of Traditional Chinese Medicine, Guangzhou 510130, Guangdong, China;
    1Departemnt of Pharacology, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, Guangdong, China;
    2Departement of Pharacology, Guangzhou Institute of Traditional Chinese Medicine and Materia Medica, Guangzhou 510130, Guangdong, China;
    3Institute of Drug Guangdong Provincial Institute of Materia Medica, Guangzhou 510180, Guangdong, China
  • Received:2004-09-29 Revised:2004-11-16 Online:2004-12-26 Published:2020-11-19

摘要: 目的: 研究荔枝核皂苷和罗格列酮对高脂血症-脂肪肝大鼠血糖血脂的影响。方法: 采用高脂血症-脂肪肝大鼠模型, 观察荔枝核皂苷和罗格列酮、格列齐特对病鼠空腹血糖(FBG)、口服葡萄糖耐量试验(OGTT) 后2 h 血糖(2hBG) 以及给药后2 h 空腹血清血糖(FSG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、血清尿素氮(BUN)、肌酐(Cr)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST) 及镜检肝组织病理学等指标的影响。结果: 荔枝核皂苷和罗格列酮能显著改善高脂血症-脂肪肝致胰岛素抵抗(IR) 模型大鼠的IGT, 降低OGTT 后2h BG 和FSG(P <0.05);并能显著降低病鼠TC、TG、LDL-C 含量(P <0.05~0.01), 显著提高HDL-C 含量(P <0.05);降低病鼠ALT、AST 活性和BUN、Cr 含量(P<0.05), 改善肝细胞脂肪变性(P <0.01) 。结论: 荔枝核皂苷和罗格列酮能提高胰岛素的敏感性, 调整高脂血症-脂肪肝所致的糖脂代谢障碍, 并具有改善病鼠肝肾功能的作用。

关键词: 荔枝核皂苷, 罗格列酮, 胰岛素抵抗, 高脂血症, 脂肪肝

Abstract: AIM: To investigate the effects of saponin of Litchi seed (SL) and roglitazone on decreasing blood glucose, Lipid and amelioration hepatic, nephritic function in hyperlipemia-fatty liver rats fed by high-sugarfat.METHODS: The animal model with hyperlipemiafatty liver was prepared in rats by feeding on high caloric diet (abounded of sugar and fat) for 10 weeks.After 6 weeks treatment, the effects of SL, roglitazone and gliclazide (intragastrointestinally administered, qd for 4 weeks) on fasting blood glucose (FBG), 2-hour blood glucose (2hBG) after oral glucose tolerance test (OGTT), serum contents of fasting glucose(FSG), total cholesterol(TC), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), blood urea nitrogen (BUN), creatine (Cr) and serum activities of alanine aminotransferase (ALT), and aspartate aminotransferase (AST) and hepatic histopathology were observed by microscope.RESULTS: After administration of SL and roglitazone, the serum concentrations of fasting blood glucose (FSG) and 2-hour blood glucose (2hBG) after oral glucose tolerance test (OGTT) significantly decreased (P <0.05);the impaired glucose tolerance (IGT) improved;the level of TG, TC, and LDL-C decreased (P <0.05);the content of HDL-C augmented (P <0.05);the concentrations of BUN and Cr, activities of ALT and AST decreased (P <0.05);and the fatty degeneration of hepatocytes improved (P <0.01). CONCLUSION: SL and roglitazone can control hyperinsulinemia, enhance insulin sensitivity, reduce level of blood glucose, regulate components and contents of blood lipid, and improve both of function in liver and kidney.

Key words: saponin of Litchi, roglitazone, insulin resistance, hyperlipemia, fatty liver

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