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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (12): 1432-1435.

• 研究原著 • 上一篇    下一篇

静脉注射和肌肉注射不同剂量rhIFNα2a 对小鼠体温的影响

王维波, 李文广, 路莉, 吴勇杰, 高明堂   

  1. 兰州大学, 甘肃省中药新药临床前研究重点实验室, 兰州 730000, 甘肃
  • 收稿日期:2004-10-06 修回日期:2004-11-17 出版日期:2004-12-26 发布日期:2020-11-19
  • 通讯作者: 李文广, 男, 教授, 硕士生导师, 研究方向:肿瘤药理学。Tel:0931-8623573
  • 作者简介:王维波, 男, 硕士研究生, 研究方向:肿瘤药理学。Tel:13139423948 E-mail:wwb11178@hotmail.com

Comparison of change of body temperature in mice induced by intravenously and intramuscularly injection of different dosage of rhIFNα2a

WANG Wei-Bo, LI Wen-Guang, LU Li, WU Yong-Jie, GAO Ming-Tang   

  1. Department of Pharmacology, Lanzhou Medical College, Gansu Province Key Laboratory of Preclinical Study for New Traditional Chinese Medicine, Lanzhou 730000, Gansu, China
  • Received:2004-10-06 Revised:2004-11-17 Online:2004-12-26 Published:2020-11-19

摘要: 目的: 研究静脉注射和肌肉注射不同剂量rhIFNα2a 对小鼠体温的影响。方法: 测量给药前后不同时间点的小鼠体温和血清rhIFNα2a 的浓度。结果: 相同剂量的rhIFNα2a 静脉注射与肌肉注射比较,引起小鼠体温升高的作用更强, 而且rhIFNα2a 引起的发热可被吲哚美辛阻断。结论: rhIFNα2a 肌肉注射较静脉注射引起不良反应轻, 对于rhIFNα2a 引起发热敏感的机体可联合用非甾体类抗炎药。

关键词: 干扰素, 内热原, 发热, 小鼠, 体温

Abstract: AIM: To study the effects of body temperature changes inmice induced by intravenously and intramuscularly injection of different dosage of rhIFNα2a. METHODS: The body temperature in mice was measured at 30 minute before and at different time after rhIFNα2a injection and the concentration of IFN in serum was measured by ELISA method.RESULTS: Intravenous injection of rhIFNα2a induced remarkably higher and longer fever than intramuscular injection.And the fever increase was inhibited by indomethacin.CONCLUSION: Intramuscular injection of rhIFNα2a shows fewer side effects than intravenous injection.Fever change sensitive to rhIFNα2a can be inhibited by using non-steroid anti-inflammatory drugs.

Key words: rhIFNα2a, endogenous pyrogen, fever, mice, temperature

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