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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (3): 253-256.

• 研究原著 • 上一篇    下一篇

两种不同结构类型的钾通道开放剂埃他卡林和吡那地尔联合用药降压作用的特征

王桂英1, 龙超良, 汪海   

  1. 军事医学科学院毒物药物研究所, 北京100850;
    1河北医科大学基础医学院, 石家庄050091, 河北
  • 收稿日期:2003-11-08 修回日期:2004-01-18 出版日期:2004-03-26 发布日期:2020-11-21
  • 通讯作者: 汪海, 男, 医学博士, 研究员, 博士生导师, 研究方向:心血管药理和新药研究。Tel:010-66932651  Fax:010-68211656  E-mail:wh@nic.bmi.ac.cn
  • 作者简介:王桂英, 女, 副教授, 研究方向:心血管生理。
  • 基金资助:
    国家“ 863” 计划重大专项(№2002AA2Z3137)

Antihypertensive characteristics of combination of iptakalim and pinacidil,potassium channel openers

WANG Gui-Ying1, LONG Chao-Liang, WANG Hai   

  1. Institute of Pharmacology and Toxicology, Academy of Millitary Medical Sciences, Beijing 100850, China;
    1Department of Physiology, Institute of Basic Medical Sciences, Hebei Medical University, Shijiazhuang 050091, Hebei, China
  • Received:2003-11-08 Revised:2004-01-18 Online:2004-03-26 Published:2020-11-21

摘要: 目的:观察两种不同种类的钾通道开放剂(potassium channel openers, KCOs) 埃他卡林(Iptakalim,Ipt) 和吡那地尔(pinacidil, Pin) 联用降压作用的特征。方法:用无创性套尾法观察药物对清醒大鼠血压和心率的影响。结果:Pin 在2.0 和4.0 mg·kg-1剂量下, 可剂量依赖性降低清醒大鼠的血压, 加快其心率。Ipt 在2.0, 4.0 和8.0 mg·kg-1剂量下, 可剂量依赖性降低血压, 但不影响心率。Ipt (2.0 ~8.0 mg·kg-1) 与Pin(4.0 mg·kg-1) 合用时, 其降压作用产生协同效应, 但加快心率的作用与Pin 相同。结论:Ipt 和Pin 降压特点不同, 二者联用的降压作用增强。

关键词: 钾通道开放剂, 吡那地尔, 埃他卡林, 血压, 心率

Abstract: AIM: To study the antihypertensive characteristics of Iptakalim (Ipt) and pinacidil (Pin), the potassium channel openers (KCOs) of aliphatic amines and guanidine monohydrate, respectively.METHODS: The conscious noninvasive method with tail cuff was performed in rats to record the systolic blood pressure (SBP) and HR.RESULTS: SBP decreased and HR increased prominently in a dose-dependent manner after treatment with Pin at the doses of 2.0 and 4.0 mg·kg-1.While treated with Ipt at the doses of 2.0, 4.0 and 8.0 mg·kg-1under the same experimental conditions, SBP decreased but HR had no significant change.When administered with Ipt and Pin simultaneously, SBP decreased synergistically, and the effects on elevating HR were equal to that of Pin.CONCLUSION: Antihypertensive characteristics of Ipt are different from that of Pin, and the antihypertensive effects can be strengthened by combination of Pin and Ipt.

Key words: potassium channel openers, pinacidil, iptakalim, blood pressure, heart rate

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