神经甾体的合成和代谢及其对神经系统作用

中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (7): 725-729.

神经甾体的合成和代谢及其对神经系统作用

王丹, 鲁映青, 于榕

复旦大学上海医学院药理系(基础), 上海200032

收稿日期:2004-04-29 修回日期:2004-06-14 出版日期:2004-07-26 发布日期:2020-11-20
通讯作者: 鲁映青,女,博士,硕士生导师,研究方向:神经药理学。Tel:021-54237309 E-mail:yqlu@shmu.edu.cn
作者简介:王丹,女,在读硕士,研究方向:神经药理学。Tel:021-64165314 E-mail:022101058@fudan.edu.cn
基金资助:
上海市自然科学基金(№02ZB14007)

The synthesis and metabolism of neurosteroids and the effects on the nervous system

WANG Dan, LU Ying-Qing, YU Rong

Department of Pharmacology, Shanghai Medical College, Fudan University, Shanghai 200032, China

Received:2004-04-29 Revised:2004-06-14 Online:2004-07-26 Published:2020-11-20

摘要/Abstract

摘要： 神经甾体是指存在于中枢和外周神经系统,不需依赖于内分泌腺体的甾体激素,包括孕烯醇酮、孕酮、别孕烯醇酮、脱氢表雄酮等,由胆固醇或其前体在相应酶的作用下在神经系统合成。神经甾体可以通过作用于GABAA 受体、NMDA 受体和σ受体发挥作用。它们对记忆、睡眠、惊厥、细胞兴奋性毒性等产生相应的作用,为某些疾病的治疗指明方向。

关键词: 神经甾体, 孕烯醇酮, 孕烯醇酮硫酸盐, 孕酮, 别孕烯醇酮, 脱氢表雄酮, 脱氢表雄酮硫酸盐, 神经系统

Abstract: Neurosteroids exist in central and peripheral nervous system, independence of peripheral glands, including pregnenolone, progesterone, allopregnanolone,and dehydroepiandrosterone, etc.They can be synthesized in the nervous system from sterol or sterol precursors catalyzed by certain enzymes.They play roles by interacting with GABAA, NMDA orσreceptors, and have effects on memory, sleep, convulsion, cellular excitability, etc.

Key words: neurosteroids, pregnenolone, progesterone, allopregnanolone, dehydroepiandrosterone, nervous system

中图分类号:

R459.1

王丹, 鲁映青, 于榕. 神经甾体的合成和代谢及其对神经系统作用[J]. 中国临床药理学与治疗学, 2004, 9(7): 725-729.

WANG Dan, LU Ying-Qing, YU Rong. The synthesis and metabolism of neurosteroids and the effects on the nervous system[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(7): 725-729.

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