Ⅱ型糖尿病大鼠不同病程期主动脉功能的改变

中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (7): 788-791.

Ⅱ型糖尿病大鼠不同病程期主动脉功能的改变

徐济良, 何敏, 郑民, 吴锋

南通医学院药理学教研室, 南通 226001, 江苏

收稿日期:2004-05-21 修回日期:2004-06-26 出版日期:2004-07-26 发布日期:2020-11-20
通讯作者: 徐济良,男,硕士,教授,硕士生导师,研究方向:心血管药理。Tel:0513-5051727 E-mail:jlxu@ntmc.edu.cn
基金资助:
江苏省教育厅科学研究基金资助项目(№JH01-076)

Function alteration of aortas at different stages of type Ⅱ diabetes rats

XU Ji-Liang, HE Min, ZHENG Min, WU Feng

Department of Pharmacology, Nantong Medical College, Nantong 226001, Jiangsu, China

Received:2004-05-21 Revised:2004-06-26 Online:2004-07-26 Published:2020-11-20

摘要/Abstract

摘要： 目的: 观察Ⅱ型糖尿病大鼠不同病程期血管对收缩剂的反应性及内皮依赖性血管舒张反应(EDVR)的改变。方法: 采用高能量饮食加小剂量腹腔注射链脲佐菌素(STZ)的方法,建立Ⅱ型糖尿病大鼠模型;观察注射STZ 后12 和20 周离体大鼠胸主动脉对苯肾上腺素(Phe)和氯化钾(KCl)引起收缩的反应性以及乙酰胆碱(Ach)引起的EDVR 反应的改变。结果: 注射STZ 后12 周,主动脉对Phe 的反应性增强,对KCl 的反应性不变,EDVR 轻度受损;注射STZ 后20 周,对Phe 的反应性进一步提高,对KCl的反应性显著增强,EDVR 明显受损。结论: Ⅱ型糖尿病大鼠大血管对血管收缩物质的反应性增强,而EDVR 则减弱,随着病程的发展这些改变进一步增加。

关键词: Ⅱ型糖尿病, 不同病程期, 主动脉, 血管收缩剂, 内皮依赖性血管舒张, 大鼠

Abstract: AIM: To investigate the alteration of the vascular response to contracting material and the endothelium dependent vascular relaxation (EDVR)at different stages of type Ⅱ diabetes rats.METHODS: Type Ⅱ diabetes rat model was established by high-energy diet and lower dose of STZ.At 12th and 20th weekends after injecting STZ, the vascular reactivities to phenylephrine (PHE)and KCl and the EDVR induced by Ach were measured respectively in the isolated aorta rings.RESULTS: At 12th weekend after injecting STZ, the response to PHE increased, the reactivity to KCl kept unchanged, and the EDVR was damaged lightly.But at the 20 th weekend after injecting STZ, the response to PHE increased further and the reactivity to KCl markedly reinforced, and the EDVR was obviously damaged.CONCLUSION: The response of great vessels to contracting material increased, but the EDVR attenuated at different stages of type Ⅱ diabetes rats.These changes are further reinforced along with the developing of disease duration.

Key words: type Ⅱ diabetes, different stages, aorta, vascular systolic material, endothelium dependent vascular relaxation, rats

中图分类号:

R965.1

徐济良, 何敏, 郑民, 吴锋. Ⅱ型糖尿病大鼠不同病程期主动脉功能的改变[J]. 中国临床药理学与治疗学, 2004, 9(7): 788-791.

XU Ji-Liang, HE Min, ZHENG Min, WU Feng. Function alteration of aortas at different stages of type Ⅱ diabetes rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(7): 788-791.

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