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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (8): 942-944.

• 研究原著 • 上一篇    下一篇

氯胺酮对腹腔感染脓毒症小鼠生存率的影响

刘芬, 陈金和1, 李声华, 赵文辉, 艾永循   

  1. 江汉大学附属医院麻醉科, 武汉430015, 湖北
  • 收稿日期:2004-04-15 修回日期:2004-06-26 出版日期:2004-08-26 发布日期:2020-11-20
  • 通讯作者: 1陈金和,男,硕士研究生导师,研究方向:神经药理学,工作单位:武汉大学医学院药学系。Tel:027-82440793 E-mail:killerlsh2000@yahoo.com.cn
  • 作者简介:刘芬,女,硕士,讲师,主治医师。

Effects of ketamine on cumulative survival in septic mice induced by cecal ligation and puncture

LIU Fen, CHEN Jin-He, LI Sheng-Hua, ZHAO Wen-Hui, AI Yong-Xun   

  1. Department of Anesthesiology, the Affiliated Hospital of JiangHan University, WuHan, 430015, Hubei, China
  • Received:2004-04-15 Revised:2004-06-26 Online:2004-08-26 Published:2020-11-20

摘要: 目的: 探讨早期使用氯胺酮是否延迟盲肠结扎穿孔(CLP)所致脓毒症小鼠的死亡时间。方法: 60只CLP小鼠,分别于术后1、6 h 腹腔注射氯胺酮0、3、6、12 mg·100 g-1,观察小鼠死亡情况并比较累计生存率。结果: 氯胺酮延长CLP小鼠死亡时间(P<0.05);氯胺酮6 mg·100 g-1组小鼠生存时间明显长于3 mg·100 g-1组和12 mg·100 g-1组(P<0.05)。结论: 氯胺酮延迟CLP小鼠死亡时间,并呈现剂量依赖性。

关键词: 氯胺酮, 盲肠结扎穿孔, 脓毒症, 小鼠, 生存率

Abstract: AIM: To investigate the dose-related effects of ketamine on cumulative survival in mice models of polymicrobial sepsis induced by cecal ligation and puncture (CLP).METHODS: Mice with CLP were divided randomly into four groups, received ketamine injection intraperitoneally of 0, 3, 6, and 12 mg·100 g-1, respectively, at 1 and 6 h after CLP.The survival rate was observed in each group.RESULTS: No change in mortality was observed after 72 hours among four groups.Ketamine administration was associated with significant improvement of the survival of mice with CLP (P<0.05), especially in 6 mg·100 g-1 group (P<0.05).CONCLUSION: Ketamine administration dose-independently delays lethality from sepsis in mice with CLP.

Key words: ketamine, cecal ligation and puncture, sepsis, mice, cumulative survival

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