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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (9): 1065-1068.

• 研究原著 • 上一篇    下一篇

射频透热联合化疗治疗恶性胸腔积液的临床评价

郭祖峰, 张帮慧, 程静   

  1. 皖南医学院弋矶山医院肿瘤内科, 芜湖241001, 安徽
  • 收稿日期:2004-08-18 修回日期:2004-08-26 出版日期:2004-09-26 发布日期:2020-11-23
  • 通讯作者: 郭祖峰, 男, 主治医师, 硕士, 研究方向:恶性肿瘤化疗及综合治疗。Tel:0553-5739311 E-mail:guozuf eng66 @sina. com

Clinical evaluation of radio-heating-chemotherapy in treatment of patients with malignant pleural effusion

GUO Zu-Feng, ZHANG Bang-Hui, CHENG Jin   

  1. Department of Oncology, Yijishan Hospital, Wannan Medical College, Wuhu 241001, Anhui, China
  • Received:2004-08-18 Revised:2004-08-26 Online:2004-09-26 Published:2020-11-23

摘要: 目的: 为了改善晚期肿瘤患者生活质量, 观察局部射频透热化疗治疗恶性胸腔积液患者的临床疗效。方法: 60 例恶性胸腔积液患者在全身化疗后采用胸腔穿刺, 中心静脉导管置入胸腔持续闭式引流排胸液。随机分成2 组, 热化疗组和化疗组。采用胸腔灌注顺铂60 mg, 2 周1 次, 其中热化疗组于灌注顺铂30 min 内进行胸部射频透热治疗60 ~ 90 min 次, 每周2 次, 热疗8 ~ 10 次。结果: 化疗组有效率67 %, 热化疗组有效率90 %, 显著高于化疗组(P<0. 05)。热化疗组生活质量评分(KPS)高于化疗组(P<0. 01)。不良反应基本相似。结论: 射频透热联合双途径化疗是目前治疗恶性胸腔积液患者有效、可行的一种方法。

关键词: 射频透热化疗, 全身化疗, 顺铂, 胸腔积液, 生活质量评分

Abstract: AIM: To evaluate the efficacy and safety on the radio-heating-chemotherapy in treatment of patients with malignant pleural effusion (MPE).METHODS: 60 patients of MPE were randomly devided into two groups, radio-chemotherapy group (treatment group)and chemotherapy group (control group).The drugs, according to the types of tumor cells, were select to take intravenous injection and pleural cavity administration. The patient' s pleural cavity was drained continuously by pleurocentesis. These treatments were made once two week lasting for 4-6 weeks with NS 30 ml +cisplatin 60 mg by perfusion of pleural cavity. After the perfusin of pleural cavity, radioheating was performed 60-90 min, twice one week for 8-10 times in the treatment group.RESULTS: The response rate was 90 % (CR+PR)in the treatment group, and 67 % (CR +PR)in the control group. The rates were higher than those in the control group (P<0. 05). Karnofsky performance status score (KPS)in the treatment group was higher than that in the control group (P<0. 01).The side effects included slight gastrointestinal tract reactions, and myelosupression in the two groups.CONCLUSION: Radio-heating-chemotherapy is an effective way in treatment of patients with malignant pleural effusion.

Key words: radio-heating-chemotherapy, intravenous chemotherapy, cisplatin, malignant pleural effusion, karnofsky performance status(KPS)score

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