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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (1): 79-82.

• 研究原著 • 上一篇    下一篇

脑益康对阿尔茨海默病模型小鼠学习记忆的影响

朱燕, 周爱玲, 茅家慧   

  1. 南通大学基础医学院病理生理学教研室, 南通 226001, 江苏
  • 收稿日期:2004-10-26 修回日期:2004-12-15 出版日期:2005-01-26 发布日期:2020-11-19
  • 通讯作者: 周爱玲, 女, 硕士, 教授, 硕士生导师, 研究方向:神经退行性病发病机制与防治研究。Tel:0513-5051732 E-mail:ailingzhou0513@163.com
  • 作者简介:朱燕, 女, 硕士研究生。Tel:0513-5051733 E-mail:jfm-snb@163.com
  • 基金资助:
    江苏省自然科学基金项目(NoBK2004048)

Effects of naoyikang on capability of learning and memory in Alzheimer's disease model mice

ZHU Yan, ZHOU Ai-ling, MAO Jia-hui   

  1. Department of Pathophysiology, School of Basic Medical Sciences, Nantong University, Nantong 226001, Jiangsu, China
  • Received:2004-10-26 Revised:2004-12-15 Online:2005-01-26 Published:2020-11-19

摘要: 目的: 观察脑益康对阿尔茨海默病(Alzheimer's disease,AD) 模型小鼠学习记忆的影响, 并探讨其改善学习记忆的机制。方法: 采用D-半乳糖(DGal)和亚硝酸钠(NaNO2) 腹腔注射建立小鼠AD 模型, 通过迷宫刺激器和水迷宫实验检测小鼠学习记忆能力;生化方法检测小鼠脑组织内超氧化物歧化酶(SOD) 活性和丙二醛(MDA) 含量;透射电镜观察小鼠海马神经细胞的超微结构。结果: 模型对照组小鼠学习记忆能力下降, SOD 活性降低, MDA 含量升高;而与模型对照组比较, 脑益康小、中、大剂量组(2.4、7.2、24 g·kg-1·d-1) 均可显著改善模型小鼠的学习记忆能力, 提高脑内SOD 活性, 降低脑内MDA含量(P <0.01或P <0.05), 阻抑海马神经细胞的退行性变化。结论: 脑益康可改善D-半乳糖和亚硝酸钠所致AD 模型小鼠的学习记忆能力。

关键词: AD 模型, 脑益康, 学习记忆, 超氧化物歧化酶, 丙二醛

Abstract: AIM: To observe the effects of naoyikang on the capability of learning and memory in Alzheimer's disease model mice.METHODS: The mice model was established by intraperitoneal injection of D-Gal and Na-NO2, the capability of learning and memory was tested on mice by electrical maze and water maze, the levels of superoxide dismutase (SOD) and malondialdehyde (MDA) of brain tissues were assayed by biochemical methods, and the changes in ultrastructure were observed by Transmission Electron Microscope.RESULTS: The capability of learning and memory of model mice decreased and the level of SOD of model mice decreased and MDA increased.Compared with the madel group, they were obviously improved in low, middle and high doses (2.4, 7.2, 24 g·kg-1·d-1) of naoyikang group (P <0.01 or P <0.05), and the degeneration of mice cells was inhibited.CONCLUSION: Naoyikang can ameliorate the capability of learning and memory in AD model mice induced by D-Gal and NaNO2.

Key words: Alzheimer's disease, animal model, naoyikang, learning and memory, superoxide dismutase, malondialdehyde

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