谷胱甘肽及其相关酶系统与肿瘤多药耐药的关系

摘要/Abstract

摘要： 临床化疗失败的重要原因是肿瘤细胞对化疗药物产生多药耐药(MDR)。经典的 P 糖蛋白、多药耐药相关蛋白等耐药机制已基本明确。因此,进一步了解非经典的耐药途径对于完善多药耐药机制有重要意义。本文综述了谷肮甘肤及其相关酶系统在肿瘤多药耐药中的作用,介导多药耐药的可能机制以及谷肮甘肤类似物结构与转运活性的关系。

关键词: 多药耐药, 谷胱甘肽, 相关酶, 转运体, 转运机制, 类似物

Abstract: Multidrug resistance to chemotherapeutic drugs is an important reason for clinieal chemotherapy failure. The mechanisms of the classical drug resistancesuch as P-gp, MRP have been clarified. Hence, it isvery important to further study the non-classical mechanism of multidrug resistance. We introduced the effects on MDR, the possible mechanisms of glutathione and relatedenzymes, as well as the relationship between structure of GSH analogues and the transport activity in this paper

Key words: multidrug resistance, glutathione, relat-enzymes, transporter, transport mechanism: analogs

中图分类号:

R979.1

蒋轶, 李运曼. 谷胱甘肽及其相关酶系统与肿瘤多药耐药的关系[J]. 中国临床药理学与治疗学, 2005, 10(10): 1086-1091.

JIANG Yi, LI Yun-man. Relationship between Glutathione and related enzymes and multidrug resistance[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(10): 1086-1091.

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