前列腺素 D2的睡眠调节作用

摘要/Abstract

摘要： 前列腺素 D₂ (PGD₂)是由前列腺素 D₂ 合成酶合成的一种二十碳不饱和脂肪酸。研究表明PGD₂ 具有睡眠调节作用,其机理为 PGD₂ 与前列腺素D₂ 受体结合,升高基底前脑部位细胞外腺苷水平。腺苷通过腺苷 A_2A 受体激活睡眠调节中枢(腹外侧视前区,VLPO)神经元,并通过 GABA 抑制觉醒调节中枢(结节乳头核,TMN)组胺能神经元而导致睡眠。对 PGD₂睡眠调节作用及其机理进行研究,有望开发出新型的镇静催眠药物。

关键词: 前列腺素 D₂, 睡眠, 前列腺素 D₂ 合成酶, 前列腺素 D₂ 受体, 腺苷, 腺苷 A_2A 受体, 组胺

Abstract: Prostaglandin (PG)D₂ is one of unsatur-ated fatty acids with 20 carbon atoms,which is synthe-sized by PGD synthase (PGDS)in the brain.PGD₂ has been identified to be a sleep-inducing substance that be-comes bound to the DPreceptor(DPR)exclusively local-ized on the surface of the basal forebrain,leading to an increase in extracellularadenosine levels there.Through A_2A receptors (A_2A R),the adenosine activates neurons in the ventrolateral preoptic area (VLPO),a putative sleePcenter,and inhibits neurons in the histaminergic tube-romammillary nucleus (TMN),a putative wake center,via GABA to induce sleep.Studying the effect and the molecularmechanismsof sleep-induced by PGD₂ would be helpful in the development of novel sleeping drugs formore rational treatment of sleePdisorders.

Key words: PGD₂, sleep, PGD synthase, DPre-ceptor, Adenosine, A_2A receptor, histamine

中图分类号:

R965文献标识码:A文章编号:1009-2501(2005)12-1321-05

傅昌芳, 洪宗元. 前列腺素 D₂的睡眠调节作用[J]. 中国临床药理学与治疗学, 2005, 10(12): 1321-1325.

FU Chang-fang, HONG Zong-yuan. Effect of prostaglandin D₂ on sleePregulation[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(12): 1321-1325.

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前列腺素 D₂的睡眠调节作用

Effect of prostaglandin D₂ on sleePregulation

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