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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (2): 204-210.

• 研究原著 • 上一篇    下一篇

氨氯地平治疗轻、中度高血压有效性与安全性的Meta 分析

朱锦秀, 李见春1, 郑青山1   

  1. 蚌埠医学院附属医院药剂科, 蚌埠233004, 安徽;
    1安徽省药物临床评价中心, 芜湖241001, 安徽
  • 收稿日期:2004-12-23 修回日期:2005-01-07 出版日期:2005-02-06 发布日期:2020-11-18
  • 通讯作者: 郑青山, 男, 博士, 教授, 从事定量药理学和临床药理学研究。Tel:0553-5738350 E-mail:zhengqs11@21cn.com
  • 作者简介:朱锦秀, 女, 执业药师。李见春, 男, 讲师, 硕士。Tel:0552-3064590-2354 E-mail:lijc66577@sina.com

Meta-analysis of efficacy and safety of amlodipine in treatment of mild to moderate hypertension

ZHU Jin-xiu, LI Jian-chun1, ZHENG Qing-shan1   

  1. Department of Pharmacy, Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui, China;
    1Anhui Provincial Center for Drug Clinical Evaluation & Yijishan Hospital, Wannan Medical College, Wuhu 241001, Anhui, China
  • Received:2004-12-23 Revised:2005-01-07 Online:2005-02-06 Published:2020-11-18

摘要: 目的:了解氨氯地平治疗轻、中度高血压有效性及不良反应(安全性) 的差异。方法:应用Meta 分析对26 篇文献28 项研究氨氯地平与其他抗高血压药物治疗轻、中度高血压的有效性、安全性进行同质性检验及合并效应量的估计。结果:(1) 同质性检验:有效性, χ2=29.13, 自由度为27;安全性, χ2=27.95, 自由度为24, 两者P 均大于0.05 。(2) 合并效应量的估计:有效性, OR合并=1.261, OR合并95%可信区间为1.018~1.562 。OR合并的检验:χ2=4.51, P<0.05;安全性:OR合并=1.013, OR合并95%可信区间为0.801~1.282 。OR合并的检验:χ2=0.013, P>0.05 。结论:氨氯地平治疗轻、中度高血压的疗效总体上优于目前常用药物, 且其安全性较高。

关键词: 氨氯地平, 高血压, 临床试验, 有效性, 安全性, Meta分析

Abstract: AIM: To explore the efficacy and safety between amlodipine in treatment of mild to moderate hypertension.METHODS: The efficacy and safety of amlodipine or other drugs in treatment of mild to moderate hypertension were analyzed by Mata-analysis in homogeneity test and combined test in 25 investigations.RESULTS: Homogeneity test showed that the cited studies of efficacy and safety were homogeous with χ2e=29.13, χ2s=27.95, P>0.05, respectively;and in combined test, the combined ORe=1.261, ORs=1.013 and its 95% confidence interval were in 1.018-1.562 and 0.801-1.282, respectively.CONCLUSION: The efficacy of amlodipine is significantly superior to those of the medications used at present in treatment of mild to moderate hypertension, and its safety is reliable.

Key words: amlodipine, hypertension, efficacy, safety, Mata-analysis

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