欢迎访问《中国临床药理学与治疗学》杂志官方网站,今天是

中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (4): 421-423.

• 研究原著 • 上一篇    下一篇

川芎嗪对小鼠 Lewis 肺癌的治疗作用

王文武, 戴西湖, 欧阳学农   

  1. 国家中西医结合肿瘤重点专科, 南京军区福州总医院肿瘤科, 福州 350025, 福建
  • 收稿日期:2005-02-20 修回日期:2005-03-14 出版日期:2005-04-26 发布日期:2020-11-19
  • 通讯作者: 王文武,男, 主治医师, 研究方向:肿瘤治疗。Tel:(0) 13950289825 E-mail:wangwwu@yahoo.com.cn

Experimental study of effects of tetramethylpyrazine on Lewis lung carci-noma in mice

WANG Wen-wu, DAI Xi-hu, OUYANG Xue-nong   

  1. Nanjing Military Command Fuzhou General Hospital, Fuzhou 350025, Fujian, China
  • Received:2005-02-20 Revised:2005-03-14 Online:2005-04-26 Published:2020-11-19

摘要: 目的: 研究中药川芎嗪(TMP) 对实体肿瘤的疗效及其可能的作用机理。方法: 本研究运用 Lewis肺癌小鼠模型, 观察 TMP 对小鼠 Lewis 肺癌的疗效 、免疫功能、生存质量及不良反应的影响。结果: TMP治疗小鼠 Lewis 肺癌能抑制肿瘤的生长, 稳定病灶,提高荷瘤小鼠的生存质量, 改善免疫功能。结论: TMP 对小鼠 Lewis 肺癌有明显疗效, 其作用机理与其本身对 Lewis 肺癌实体瘤有抑制作用和提高荷瘤小鼠免疫功能有关。

关键词: 川芎嗪, Lewis 肺癌, 肺, 肿瘤

Abstract: AIM: To study the therapeutic effects of tetramethylpyrazine (TMP) in mice and possible mecha-nism. METHODS: The mice with Lewis lung carcinoma was used as a model for observing the therapeutic effect, the immunomodulatory functions, changes of quality of life, and adverse reactionsof TMP. RESULTS: TMP in-hibited the growth of tumor, and increased life quality and the immunity of mice with Lewis lung carcinoma. CONCLUSION: TMP have therapeutic effects in mice with Lewis lung carcinoma. Its mechanism might be associated with improving the immunity of mice with Lewis lung car-cinoma.

Key words: tetramethylpyrazine, Lewis lung carci-noma, lung, cancer

中图分类号: