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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (4): 432-435.

• 研究原著 • 上一篇    下一篇

葡萄糖酸镁对大鼠心肌缺血再灌注损伤的保护作用

张莹, 齐志敏, 郭磊, 高东明1, 王化洲   

  1. 锦州医学院药理学教研室,1生理学教研室, 锦州 121001, 辽宁
  • 收稿日期:2005-01-14 修回日期:2005-03-21 出版日期:2005-04-26 发布日期:2020-11-19
  • 通讯作者: 王化洲,男, 教授, 硕士生导师, 研究方向:心血管药理。
  • 作者简介:张莹, 女, 硕士研究生, 研究方向:心血管药理。Tel:13125607920 E-mail:zhangying1977cn@yahoo.com.cn
  • 基金资助:
    辽宁省教育厅科研基金资助项目(NOA20072106)

Cardioprotective effects of magnesium gluconate on myocardial ischemia reperfusion injury in rats

ZHANG Ying, Qi Zhi-min, GUO Lei, GAO Dong-ming1, WANG Hua-zhou   

  1. Department of Pharmacology,1Department of Physiology, Jinzhou Medical College, Jinzhou121001, Liaoning, China
  • Received:2005-01-14 Revised:2005-03-21 Online:2005-04-26 Published:2020-11-19

摘要: 目的: 观察葡萄糖酸镁对心肌缺血再灌注损伤的影响, 探讨葡萄糖酸镁心肌保护作用及其机理。方法: 采用改进了的整体大鼠急性心肌缺血再灌注损伤模型, 检测组织内 Na+-K+ -ATPase 活力及丙二醛(MDA) 和 Ca2+ 含量, 并测定由ADP 诱导的血小板5 min 最大聚集率 AGG(M)。结果: 与假手术组相比, 缺血再灌注组心肌组织内 Na+ -K+ -ATPase 活力显著下降(P<0.01), MDA 和Ca2+ 含量明显升高(P<0.01), AGG(M) 升高(P<0.05)。与缺血再灌注组比较, 葡萄糖酸镁 3 个不同剂量保护组心肌组织内Na+ -K+-ATPase 活力明显升高(P<0.01), MDA和Ca2+ 含量明显降低(P<0.05 或 P <0.01), AGG(M) 也明显降低(P<0.01), 且各作用均随用药剂量的增加而更加显著。结论: 葡萄糖酸镁对心肌缺血再灌注损伤有保护作用, 其保护作用机制与增加Na+ -K+-ATPase 活性 、减轻钙超载和抑制脂质过氧化反应以及血小板聚集有关。

关键词: 葡萄糖酸镁, 心肌缺血再灌注损伤, 血小板聚集, Na+-K+-ATPase, MDA

Abstract: AIM: To observe the effects of magne-sium gluconate on myocardial ischemia reperfusion injury in anesthetized rats and to investigate the cardioprotective effects of magnesium gluconate. METHODS: The im-proved model of myocardial ischemia reperfusion injury in anesthetized ratswas adopted. Na+-K+ -ATPase activity, malondialdehyde (MDA) and Ca2+ contents in myocardi-um were assayed.The platelet aggregation AGG(M) and Mg2+ in blood serum were assayed at the same time. RESULTS: Na+ -K+ -ATPase activity decreased and MDA and Ca2+ contents increased in the ischemia reperfusion group compared with sham.The AGG(M) and Na+ -K+ ATPase activity increased, and MDA and Ca2+ contents and AGG (M) decreased in the three different dosages group of magnesium gluconate comparedwith the ischemia reperfusion group.The cardioprotective effects increased with the dose increasing of magnesium gluconate. CONCLUSION: Magnesium gluconate has protective effects on myocardial ischemia reperfusion injury in rats.It may be related to increasing the activity of Na+ -K+ -ATPase, and to relieving calcium overload and inhibiting lipid per-oxidation and platelet aggregation.

Key words: magnesium gluconate, myocardial is-chemia reperfusion injury, platelet aggregation, Na+-K+-ATPase, MDA

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